MOSAIC: an online database dedicated to the comparative genomics of bacterial strains at the intra-species level.
MOSAIC: an online database dedicated to the comparative genomics of bacterial strains at the intra-species level.
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Mosaic：一个在线数据库，该数据库专用于细菌菌株的比较基因组学水平。
DOI：
10.1186/1471-2105-9-498
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发表时间：
2008-11-27
影响因子：
3
通讯作者：
El Karoui M
中科院分区：
文献类型：
--
作者：
Chiapello H;Gendrault A;Caron C;Blum J;Petit MA;El Karoui M
最近许多密切相关的细菌基因组的完整序列的出现给比较基因组学带来了新的挑战。已经开发了几种在核苷酸水平上比对完整基因组的方法，但它们的使用和结果的生物学解释并不简单。因此，有必要开发新的资源来访问、分析和可视化基因组比较。在这里，我们介绍 MOSAIC（通用比较细菌基因组数据库）的最新进展。该数据库为细菌学家群体提供了在种内水平上轻松比较完整细菌基因组的方法。我们开发的比较策略使我们能够定义细菌基因组中的两种类型的区域：主干片段（即在所有比较菌株中保守的区域）和可变片段（即比对基因组之一特有或可变的区域）。在核苷酸水平上定义这些片段可以对细菌基因组的编码区和非编码区进行精确的比较和进化分析。此类工作可以使用 MOSAIC Web 界面轻松执行，该界面允许基因组比较的浏览和图形可视化。 MOSAIC 数据库现在包括 493 个配对比较和 35 个多重最大比较，代表 78 个细菌物种。基因组保守区域（主链）和可变片段以各种格式呈现以供进一步分析。图形界面允许对齐的基因组和功能注释的可视化。 MOSAIC 数据库可在线获取，网址为 。
The recent availability of complete sequences for numerous closely related bacterial genomes opens up new challenges in comparative genomics. Several methods have been developed to align complete genomes at the nucleotide level but their use and the biological interpretation of results are not straightforward. It is therefore necessary to develop new resources to access, analyze, and visualize genome comparisons. Here we present recent developments on MOSAIC, a generalist comparative bacterial genome database. This database provides the bacteriologist community with easy access to comparisons of complete bacterial genomes at the intra-species level. The strategy we developed for comparison allows us to define two types of regions in bacterial genomes: backbone segments (i.e., regions conserved in all compared strains) and variable segments (i.e., regions that are either specific to or variable in one of the aligned genomes). Definition of these segments at the nucleotide level allows precise comparative and evolutionary analyses of both coding and non-coding regions of bacterial genomes. Such work is easily performed using the MOSAIC Web interface, which allows browsing and graphical visualization of genome comparisons. The MOSAIC database now includes 493 pairwise comparisons and 35 multiple maximal comparisons representing 78 bacterial species. Genome conserved regions (backbones) and variable segments are presented in various formats for further analysis. A graphical interface allows visualization of aligned genomes and functional annotations. The MOSAIC database is available online at .
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影响因子：
14.9
作者：
Florea, L;McClelland, M;Miller, W
通讯作者：
Miller, W
影响因子：
14.9
作者：
Kersey, P;Bower, L;Apweiler, R
通讯作者：
Apweiler, R
影响因子：
4.5
作者：
Halpern, David;Chiapello, Helene;El Karoui, Meriem
通讯作者：
El Karoui, Meriem
影响因子：
14.9
作者：
Chenna, R;Sugawara, H;Thompson, JD
通讯作者：
Thompson, JD
影响因子：
5.8
作者：
Stothard, P;Wishart, DS
通讯作者：
Wishart, DS