Genetically identified neurons in avian auditory pallium mirror core principles of their mammalian counterparts.
Genetically identified neurons in avian auditory pallium mirror core principles of their mammalian counterparts.
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DOI：
10.1016/j.cub.2021.04.039
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发表时间：
2021-07-12
期刊：
影响因子：
--
通讯作者：
Remage-Healey L
中科院分区：
文献类型：
--
作者：
Spool JA;Macedo-Lima M;Scarpa G;Morohashi Y;Yazaki-Sugiyama Y;Remage-Healey L
在脊椎动物中，高级认知能力通常与端脑皮质相关。在哺乳动物中，大脑皮层是兴奋性和抑制性神经元群的分层混合物，具有不同的分子、生理和网络表型。这种皮质架构旨在支持高效、高级的信息处理。脊椎动物的比较视角为理解大脑皮层的共同特征提供了一个视角，这些特征对高级认知很重要。对鸣禽的研究已经证实哺乳动物和鸟类大脑皮层的神经元类型具有惊人的相似特征。然而，非哺乳动物脊椎动物中缺乏特定的大脑皮层细胞类型的遗传途径阻碍了解决分子和生理表型之间联系的进展。鸟类大脑皮层细胞的生理学与其分子特性的明确映射对于理解突触和计算特性如何依赖于潜在的分子表型至关重要。使用病毒工具针对斑胸草雀听觉关联大脑皮层中的兴奋性与抑制性神经元（分别为 CaMKIIα 和 GAD1 启动子），我们系统地测试了来自哺乳动物大脑皮层的预测。我们鉴定了两个遗传上不同的神经元群，它们与哺乳动物的兴奋性和抑制性大脑皮层细胞表现出深刻的生理和计算相似性，明确地将鸟类尾部巢状大脑皮层中的假定细胞类型与这些分子特性对齐。具体来说，鸟类听觉关联大脑皮层中基因鉴定的 CaMKIIα 和 GAD1 细胞类型表现出不同的内在生理参数、不同的听觉编码原理以及抑制依赖性大脑皮层同步、伽马振荡和局部抑制。鸟类和哺乳动物中这些分子和生理特征的保留或融合阐明了高级认知能力的大脑皮层回路的特征。线轴等人。在鸟类大脑皮层中使用细胞类型特异性病毒光遗传学，并观察哺乳动物大脑皮层兴奋性和抑制性细胞类型中的镜像生理学、听觉编码和网络作用。因此，古代大脑皮层细胞类型很可能保留了广泛的特征来支持遥远脊椎动物的认知功能。
In vertebrates, advanced cognitive abilities are typically associated with the telencephalic pallium. In mammals, the pallium is a layered mixture of excitatory and inhibitory neuronal populations with distinct molecular, physiological, and network phenotypes. This cortical architecture is proposed to support efficient, high-level information processing. Comparative perspectives across vertebrates provide a lens to understand the common features of pallium that are important for advanced cognition. Studies in songbirds have established strikingly parallel features of neuronal types between mammalian and avian pallium. However, lack of genetic access to defined pallial cell types in non-mammalian vertebrates has hindered progress in resolving connections between molecular and physiological phenotypes. A definitive mapping of the physiology of pallial cells onto their molecular identities in birds is critical for understanding how synaptic and computational properties depend on underlying molecular phenotypes. Using viral tools to target excitatory vs. inhibitory neurons in the zebra finch auditory association pallium (CaMKIIα and GAD1 promoters respectively), we systematically tested predictions derived from mammalian pallium. We identified two genetically-distinct neuronal populations that exhibit profound physiological and computational similarities with mammalian excitatory and inhibitory pallial cells, definitively aligning putative cell types in avian caudal nidopallium with these molecular identities. Specifically, genetically-identified CaMKIIα and GAD1 cell types in avian auditory association pallium exhibit distinct intrinsic physiological parameters, distinct auditory coding principles, and inhibitory-dependent pallial synchrony, gamma oscillations, and local suppression. The retention or convergence of these molecular and physiological features in both birds and mammals clarifies the characteristics of pallial circuits for advanced cognitive abilities. Spool et al. use cell-type specific viral optogenetics in bird pallium and observe mirrored physiology, auditory coding, and network roles as in mammalian pallial excitatory and inhibitory cell types. Ancient pallial cell types therefore most likely retained an extensive array of features to support cognitive function in distant vertebrate classes.
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影响因子：
25
作者：
Cruikshank, Scott J.;Lewis, Timothy J.;Connors, Barry W.
通讯作者：
Connors, Barry W.
影响因子：
16.2
作者：
Amir A;Headley DB;Lee SC;Haufler D;Paré D
通讯作者：
Paré D
DOI：
10.1073/pnas.93.5.1950
发表时间：
1996-03-05
影响因子：
11.1
作者：
Chew, SJ;Vicario, DS;Nottebohm, F
通讯作者：
Nottebohm, F
影响因子：
5.3
作者：
Dagostin, Andre A.;Lovell, Peter V.;Leao, Ricardo M.
通讯作者：
Leao, Ricardo M.
影响因子：
2.7
作者：
Cobos, I;Puelles, L;Martínez, S
通讯作者：
Martínez, S