Vigilance-Associated Gamma Oscillations Coordinate the Ensemble Activity of Basolateral Amygdala Neurons.
Vigilance-Associated Gamma Oscillations Coordinate the Ensemble Activity of Basolateral Amygdala Neurons.
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DOI：
10.1016/j.neuron.2017.12.035
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发表时间：
2018-02-07
期刊：
影响因子：
16.2
通讯作者：
Paré D
中科院分区：
文献类型：
--
作者：
Amir A;Headley DB;Lee SC;Haufler D;Paré D
基底外侧杏仁核（BL）的主要神经元深刻地影响动机性行为，但很少有被激活的情绪效价的刺激。在这里，我们表明，这种矛盾的一个可能的解释是同步的影响，高伽玛节奏。高伽马（75-95 Hz）比所有其他节律更强烈地诱导BL放电。在提高警惕的状态下，当老鼠感到恐惧时，这一点最为明显。相对于行为状态，高伽马产生的放电率变化很小，但同步性却显著增加。此外，连接的细胞对显示出类似的高水平的夹带和同步。出乎意料的是，前额叶和脑桥投射细胞分别表现出高和低夹带高γ，表明这种节奏差异化的BL神经元的活动投射到特定的网站。总的来说，我们的研究结果表明，单个BL神经元不仅通过改变它们的放电率来编码信息，而且还通过同步它们的集体活动来编码信息，放大它们对目标结构的影响。
Principal basolateral amygdala (BL) neurons profoundly influence motivated behaviors, yet few of them are activated by emotionally-valenced stimuli. Here we show that a likely explanation for this paradox is the synchronizing influence of the high-gamma rhythm. High-gamma (75–95 Hz) entrained BL firing more strongly than all other rhythms. It was most pronounced during states of increased vigilance, when rats were apprehensive. Relative to behavioral states, high-gamma produced minor changes in firing rates yet dramatic increases in synchrony. Moreover, connected pairs of cells showed similarly high levels of entrainment and synchronization. Unexpectedly, prefrontal- and accumbens-projecting cells respectively showed high and low entrainment by high-gamma, indicating that this rhythm differentially synchronizes the activity of BL neurons projecting to specific sites. Overall, our findings suggest that individual BL neurons not only encode information by changing their firing rates but also by synchronizing their collective activity, amplifying their impact on target structures.
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