Highlighting the Versatility of the Tracerlab Synthesis Modules. Part 1: Fully Automated Production of [F]Labelled Radiopharmaceuticals using a Tracerlab FX(FN).

Highlighting the Versatility of the Tracerlab Synthesis Modules. Part 1: Fully Automated Production of [F]Labelled Radiopharmaceuticals using a Tracerlab FX(FN).
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DOI:
10.1002/jlcr.1865
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发表时间:
2011-05-30
影响因子:
1.8
通讯作者:
Scott, Peter J. H.
Scott, Peter J. H.
中科院分区:
医学4区
文献类型:
--
作者:
Shao, Xia;Hoareau, Raphael;Hockley, Brian G.;Tluczek, Louis J. M.;Henderson, Bradford D.;Padgett, Henry C.;Scott, Peter J. H.

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放射化学领域正朝着专门使用自动化合成模块生产临床放射性药物剂量的方向发展。此举具有许多优点,但也给放射化学家带来了重新配置合成模块以生产需要非传统放射化学的放射性药物同时保持完全自动化的挑战。本综述通过介绍用于生产[18 F]FLT、[18 F]FAZA、[18 F]MPPF、[18 F]FEOBV、[18 F]氟化钠、[18 F]氟代胆碱和[18 F]SFB的简单、全自动化方法,展示了Tracerlab FXFN合成模块的多功能性。
The field of radiochemistry is moving towards exclusive use of automated synthesis modules for production of clinical radiopharmaceutical doses. Such a move comes with many advantages, but also presents radiochemists with the challenge of re-configuring synthesis modules for production of radiopharmaceuticals that require non-conventional radiochemistry whilst maintaining full automation. This review showcases the versatility of the Tracerlab FXFN synthesis module by presenting simple, fully automated methods for producing [18F]FLT, [18F]FAZA, [18F]MPPF, [18F]FEOBV, [18F]sodium fluoride, [18F]fluorocholine and [18F]SFB.
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