Focal and nonfocal prospective memory performance in very mild dementia: a signature decline.
Focal and nonfocal prospective memory performance in very mild dementia: a signature decline.
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DOI：
10.1037/a0021682
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发表时间：
2011-05
期刊：
影响因子：
2.4
通讯作者：
Balota, David A.
中科院分区：
文献类型：
--
作者：
McDaniel, Mark A.;Shelton, Jill Talley;Breneiser, Jennifer E.;Moynan, Sarah;Balota, David A.
在最近的一项研究中，在某种前瞻性记忆任务（PM）上的表现，标记为焦点PM，对阿尔茨海默病（AD）的早期阶段很敏感。本研究试图通过调查局灶性和非局灶性PM以及载脂蛋白E（APOE）基因等位基因的可能影响来复制和扩展这些发现。35名健康的老年人和33名处于AD最早期的成年人（由临床痴呆评定量表确定）完成了焦点和非焦点PM任务。这些任务的性能已被链接到定性不同的认知过程，从而提供了杠杆作用，以照亮在非常早期的AD PM失败的具体过程。每组中大约一半的成年人是APOE e4携带者，一半是非携带者。我们还获得了参与者在一系列标准心理测试中的分数。PM任务的类型和痴呆状态之间存在显著的相互作用，p <0.05。η2p = 0.12，表明局灶性PM的AD相关下降比非局灶性PM更稳健。此外，焦点PM性能显着区分AD和正常老化的最早阶段，解释方差独特的典型的心理指标解释。然而，APOE状态与PM性能无关。在局灶性PM任务中观察到的明显缺陷表明，自发检索过程可能会受到损害，在非常早期的AD。
In a recent study, performance on a certain kind of prospective memory task (PM), labeled focal PM, was sensitive to the very early stages of Alzheimer’s disease (AD). The present study sought to replicate and extend these findings by investigating both focal and non-focal PM, as well as possible influences of alleles of the apolipoprotein E (APOE) gene. Thirty-five healthy older adults and 33 adults in the very earliest stages of AD, as determined by the clinical dementia rating scale, completed both focal and non-focal PM tasks. Performance on these tasks has been linked to qualitatively different cognitive processes, thereby providing leverage to illuminate the specific processes underlying PM failures in very early AD. Approximately half of the adults in each group were APOE e4 carriers and half were non-carriers. We also obtained participants’ scores on a battery of standard psychometric tests. There was a significant interaction between the type of PM task and dementia status, p < .05. η2p = .12, demonstrating that the AD-related decline was more robust for focal than for non-focal PM. Further, focal PM performance significantly discriminated between the very earliest stages of AD and normal aging, explaining variance unique to that explained by typical psychometric indices. APOE status, however, was not associated with PM performance. The pronounced deficit observed in the focal PM task suggests that spontaneous retrieval processes may be compromised in very early AD.
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影响因子：
2.4
作者：
McDaniel, MA;Glisky, EL;Routhieaux, BC
通讯作者：
Routhieaux, BC
影响因子：
2.4
作者：
Foster, Erin R.;McDaniel, Mark A.;Repovs, Grega;Hershey, Tamara
通讯作者：
Hershey, Tamara
DOI：
10.1017/s1355617708090127
发表时间：
2009-01-01
影响因子：
2.6
作者：
Blanco-Campal, Alberto;Coen, Robert F.;Burke, Teresa E.
通讯作者：
Burke, Teresa E.
影响因子：
2.6
作者：
Burgess, PW;Scott, SK;Frith, CD
通讯作者：
Frith, CD
影响因子：
3.7
作者：
Maylor, EA
通讯作者：
Maylor, EA