Activation of the Epstein-Barr virus lytic cycle by the latex of the plant Euphorbia tirucalli.
Activation of the Epstein-Barr virus lytic cycle by the latex of the plant Euphorbia tirucalli.
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植物欣快的tirucalli乳胶激活爱泼斯坦 - 巴尔病毒裂解周期。
DOI：
10.1038/sj.bjc.6600929
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发表时间：
2003-05-19
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
--
作者：
暴露于植物大戟已被提出是一个辅助因素的发生地方性伯基特淋巴瘤（eBL）。本研究的目的是检测未纯化的E. tirucalli乳胶对EB病毒（EBV）基因表达的影响。用不同稀释度的乳胶处理伯基特淋巴瘤细胞系，并测量对EBV基因表达的影响。我们观察到乳胶能够以剂量依赖性方式重新激活EBV裂解周期，并且稀释度低至10−6。同时用E. tirucalli乳胶和蛋白激酶C抑制剂1-（5-异喹啉磺酰基）-2-甲基哌嗪二盐酸盐阻断了裂解循环激活。这些数据表明，环境暴露于E。tirucalli可直接激活EBV裂解周期，为E. tirucalli在eBL病因学中的作用。
Exposure to the plant Euphorbia tirucalli has been proposed to be a cofactor in the genesis of endemic Burkitt's lymphoma (eBL). The purpose of this study was to examine the effects of unpurified E. tirucalli latex on Epstein–Barr virus (EBV) gene expression. A Burkitt lymphoma cell line was treated with varying dilutions of the latex and the effects on EBV gene expression were measured. We observed that the latex was capable of reactivating the EBV lytic cycle in a dose-dependent manner and at dilutions as low as 10−6. Simultaneous treatment of cells with E. tirucalli latex and the protein kinase C inhibitor 1-(5-isoquinolinesulphonyl)-2-methylpiperazine dihydrochloride blocked lytic cycle activation. These data suggest that environmental exposure to the latex of E. tirucalli could directly activate the EBV lytic cycle and provide further evidence of a role for E. tirucalli in the aetiology of eBL.
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CHOMCZYNSKI, P;SACCHI, N
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