Microstructural brain tissue changes contribute to cognitive and mood deficits in adults with type 2 diabetes mellitus.
Microstructural brain tissue changes contribute to cognitive and mood deficits in adults with type 2 diabetes mellitus.
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DOI：
10.1038/s41598-023-35522-9
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发表时间：
2023-06-14
影响因子：
4.6
通讯作者：
Kumar, Rajesh
中科院分区：
文献类型：
--
作者：
Roy, Bhaswati;Choi, Sarah E.;Freeby, Matthew J.;Kumar, Rajesh
2型糖尿病(T2 DM)患者表现出情绪和认知调节部位的脑组织改变，但组织损伤的性质和程度及其与症状的关系尚不清楚。我们的目的是使用扩散张量成像(DTI)计算的平均弥散率(MD)来检查T2 DM组与对照组的脑组织损害，并评估T2 DM组与情绪和认知症状的相关性。我们收集了169名受试者(68名T2 DM和101名对照组)的DTI系列(MRI)、情绪和认知数据。对T2 DM受试者的全脑MD图进行计算、归一化、平滑和组间比较，并与心境和认知得分进行相关分析。与对照组相比，2型糖尿病患者的认知和情绪功能发生了改变。T2 DM患者多个脑区MD值升高，提示有慢性组织改变，包括小脑、脑岛、额叶和前额叶皮质、扣带回和舌回。MD值与情绪和认知分数之间的关联出现在调节这些功能的大脑部位。2型糖尿病患者主要表现为调节情绪和认知功能的区域的慢性脑组织变化，这些区域的组织变化与情绪和认知症状相关，这表明脑微结构的变化可能是观察到的功能缺陷的原因。
Type 2 diabetes mellitus (T2DM) patients show brain tissue changes in mood and cognitive regulatory sites, but the nature and extent of tissue injury and their associations with symptoms are unclear. Our aim was to examine brain tissue damage in T2DM over controls using mean diffusivity (MD) computed from diffusion tensor imaging (DTI), and assess correlations with mood and cognitive symptoms in T2DM. We collected DTI series (MRI), mood, and cognitive data, from 169 subjects (68 T2DM and 101 controls). Whole-brain MD-maps were calculated, normalized, smoothed, and compared between groups, as well as correlated with mood and cognition scores in T2DM subjects. Type 2 diabetes patients showed altered cognitive and mood functions over control subjects. Multiple brain sites in T2DM patients showed elevated MD values, indicating chronic tissue changes, including the cerebellum, insula, and frontal and prefrontal cortices, cingulate, and lingual gyrus. Associations between MD values and mood and cognition scores appeared in brain sites mediating these functions. Type 2 diabetes patients show predominantly chronic brain tissue changes in areas mediating mood and cognition functions, and tissue changes from those regions correlate with mood and cognitive symptoms suggesting that the microstructural brain changes may account for the observed functional deficits.
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影响因子：
7.7
作者：
Musen G;Jacobson AM;Bolo NR;Simonson DC;Shenton ME;McCartney RL;Flores VL;Hoogenboom WS
通讯作者：
Hoogenboom WS
DOI：
10.1016/j.nicl.2017.07.004
发表时间：
2017
期刊：
NeuroImage. Clinical
影响因子：
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作者：
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通讯作者：
Mayeux, Richard
影响因子：
10.5
作者：
Baldwin, RC;O'Brien, J
通讯作者：
O'Brien, J
影响因子：
5.7
作者：
Egede, Leonard E.;Walker, Rebekah J.;Dismuke, Clara E.
通讯作者：
Dismuke, Clara E.