Resting-state brain functional connectivity is altered in type 2 diabetes.
Resting-state brain functional connectivity is altered in type 2 diabetes.
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DOI：
10.2337/db11-1669
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发表时间：
2012-09
期刊：
影响因子：
7.7
通讯作者：
Hoogenboom WS
中科院分区：
文献类型：
--
作者：
Musen G;Jacobson AM;Bolo NR;Simonson DC;Shenton ME;McCartney RL;Flores VL;Hoogenboom WS
2型糖尿病(T2 DM)是阿尔茨海默病(AD)的危险因素。在认知功能障碍之前，AD高危人群的默认模式网络(DMN)中的大脑活动发生了变化。我们在T2 DM患者中评估了这种脑模式。对10例T2 DM患者(n=10，年龄56±2.2岁，空腹血糖=8.4±1.3 mmol/L，HbA1c=7.5±0.54%)与11例年龄匹配的非糖尿病对照组(n=11，年龄=54±1.8岁，空腹血糖=4.8±0.2 mm ol/L)进行比较，以评价DMN区之间的功能连接强度。我们还通过胰岛素抵抗的稳态模型评估(HOMA-IR)评估了海马体体积、认知能力和胰岛素敏感性。对照组与T2 DM患者的双侧扣带回种子核(β=0.67vs.0.43)、右下额内侧回(β=0.75vs.0.54)、左侧丘脑(β=0.59vs.0.37)在认知和海马区大小上无差异。在T2 DM患者中，HOMA-IR与右额下回和楔前回的功能连接性呈负相关。与对照组相比，T2 DM患者DMN的功能连接性降低，这与所选脑区的胰岛素抵抗有关，但不存在脑结构或认知的群体效应。
Type 2 diabetes mellitus (T2DM) is a risk factor for Alzheimer disease (AD). Populations at risk for AD show altered brain activity in the default mode network (DMN) before cognitive dysfunction. We evaluated this brain pattern in T2DM patients. We compared T2DM patients (n = 10, age = 56 ± 2.2 years, fasting plasma glucose [FPG] = 8.4 ± 1.3 mmol/L, HbA1c = 7.5 ± 0.54%) with nondiabetic age-matched control subjects (n = 11, age = 54 ± 1.8 years, FPG = 4.8 ± 0.2 mmol/L) using resting-state functional magnetic resonance imaging to evaluate functional connectivity strength among DMN regions. We also evaluated hippocampal volume, cognition, and insulin sensitivity by homeostasis model assessment of insulin resistance (HOMA-IR). Control subjects showed stronger correlations versus T2DM patients in the DMN between the seed (posterior cingulate) and bilateral middle temporal gyrus (β = 0.67 vs. 0.43), the right inferior and left medial frontal gyri (β = 0.75 vs. 0.54), and the left thalamus (β = 0.59 vs. 0.37), respectively, with no group differences in cognition or hippocampal size. In T2DM patients, HOMA-IR was inversely correlated with functional connectivity in the right inferior frontal gyrus and precuneus. T2DM patients showed reduced functional connectivity in the DMN compared with control subjects, which was associated with insulin resistance in selected brain regions, but there were no group effects of brain structure or cognition.
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