Microstructural abnormalities in white and gray matter in obese adolescents with and without type 2 diabetes.
Microstructural abnormalities in white and gray matter in obese adolescents with and without type 2 diabetes.
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DOI：
10.1016/j.nicl.2017.07.004
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Allen HA
中科院分区：
文献类型：
--
作者：
Nouwen A;Chambers A;Chechlacz M;Higgs S;Blissett J;Barrett TG;Allen HA
在成年人中，即使没有痴呆，2 型糖尿病和肥胖也与大脑结构变化有关。一些证据表明患有 2 型糖尿病的青少年也有类似的变化，但缺乏与非肥胖对照组的比较。本研究的目的是检查患有 2 型糖尿病的青少年、肥胖青少年和健康体重青少年之间灰质和白质微观结构的差异。磁共振成像数据收集自 15 名患有 2 型糖尿病的青少年、21 名肥胖青少年和 22 名健康体重对照者。使用基于体素的形态学检查三组之间灰质的体积差异，同时使用基于束的空间统计来检查白质微观结构的差异。与健康体重对照者相比，患有 2 型糖尿病的青少年和肥胖青少年的右侧海马体、左侧壳核和尾状核、双侧杏仁核和左侧丘脑的灰质体积减少。 2型糖尿病还与胼胝体、穹窿、左额枕下束、左钩突、左内囊和外囊内分数各向异性的显着区域变化相关。这些束内各向异性分数的减少可以通过径向扩散率增加来解释，这可能表明白质束脱髓鞘。各组之间的平均扩散率和轴向扩散率没有差异。我们的数据显示，青少年肥胖本身就会导致灰质体积减少，而青少年 2 型糖尿病与白质和灰质异常相关。青少年 2 型糖尿病和肥胖与灰质体积减少有关。 2 型糖尿病与 FA 的显着区域变化相关。这些区域内 FA 的减少可以通过 RD 的增加来解释。各组之间的平均扩散率和轴向扩散率没有差异。
In adults, type 2 diabetes and obesity have been associated with structural brain changes, even in the absence of dementia. Some evidence suggested similar changes in adolescents with type 2 diabetes but comparisons with a non-obese control group have been lacking. The aim of the current study was to examine differences in microstructure of gray and white matter between adolescents with type 2 diabetes, obese adolescents and healthy weight adolescents. Magnetic resonance imaging data were collected from 15 adolescents with type 2 diabetes, 21 obese adolescents and 22 healthy weight controls. Volumetric differences in the gray matter between the three groups were examined using voxel based morphology, while tract based spatial statistics was used to examine differences in the microstructure of the white matter. Adolescents with type 2 diabetes and obese adolescents had reduced gray matter volume in the right hippocampus, left putamen and caudate, bilateral amygdala and left thalamus compared to healthy weight controls. Type 2 diabetes was also associated with significant regional changes in fractional anisotropy within the corpus callosum, fornix, left inferior fronto-occipital fasciculus, left uncinate, left internal and external capsule. Fractional anisotropy reductions within these tracts were explained by increased radial diffusivity, which may suggest demyelination of white matter tracts. Mean diffusivity and axial diffusivity did not differ between the groups. Our data shows that adolescent obesity alone results in reduced gray matter volume and that adolescent type 2 diabetes is associated with both white and gray matter abnormalities. Type 2 diabetes and obesity in adolescents is associated with reduced gray matter volume. Type 2 diabetes was associated with significant regional changes in FA. FA reductions within these tracts were explained by increased RD. Mean diffusivity and axial diffusivity did not differ between the groups.
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DOI：
10.1016/s1474-4422(12)70241-7
发表时间：
2012-12
期刊：
The Lancet. Neurology
影响因子：
--
作者：
Maillard P;Seshadri S;Beiser A;Himali JJ;Au R;Fletcher E;Carmichael O;Wolf PA;DeCarli C
通讯作者：
DeCarli C
影响因子：
7.7
作者：
Hoogenboom WS;Marder TJ;Flores VL;Huisman S;Eaton HP;Schneiderman JS;Bolo NR;Simonson DC;Jacobson AM;Kubicki M;Shenton ME;Musen G
通讯作者：
Musen G
影响因子：
5.7
作者：
Anan, Futoshi;Masaki, Takayuki;Yoshimatsu, Hironobu
通讯作者：
Yoshimatsu, Hironobu
影响因子：
19.7
作者：
Courchesne, E;Chisum, HJ;Press, GA
通讯作者：
Press, GA
影响因子：
8.2
作者：
MATTHEWS, DR;HOSKER, JP;TURNER, RC
通讯作者：
TURNER, RC