Reduced Inferior and Orbital Frontal Thickness in Adolescent Bulimia Nervosa Persists Over Two-Year Follow-Up.
Reduced Inferior and Orbital Frontal Thickness in Adolescent Bulimia Nervosa Persists Over Two-Year Follow-Up.
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DOI：
10.1016/j.jaac.2017.08.008
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发表时间：
2017-10
影响因子：
13.3
通讯作者：
Marsh R
中科院分区：
文献类型：
--
作者：
Cyr M;Kopala-Sibley DC;Lee S;Chen C;Stefan M;Fontaine M;Terranova K;Berner LA;Marsh R
横截面数据表明，神经性贪食症（BN）的下额叶和眶额叶区域的功能和解剖学障碍。使用纵向数据，我们调查是否减少皮质厚度（CT）在这些地区出现早期和持续超过青春期BN，独立于症状缓解，以及CT减少是否BN症状的标志物。33名患有BN症状（BN或其他特定喂养或进食障碍）的青少年女性和28名健康青少年参与了这项研究。在青春期2年内的3个时间点采集解剖磁共振成像和临床数据，两次评估之间的平均磨损率为31%。使用感兴趣区域的方法，我们评估了基线和随时间推移的CT组间差异，并测试了受试者之间和受试者内的CT变化是否与BN症状的频率相关。与健康青少年相比，BN的右额下回CT降低持续到青春期，即使在那些完全或部分缓解的青少年中也是如此。在BN组中，下额叶和眶额叶CT的受试者间差异与特定BN症状呈负相关，表明随着时间的推移，BN症状更频繁的受试者CT降低更大。额叶下部CT降低可能导致疾病持续到成年。下额区和眶额区厚度的减少可能是BN症状的标志。由于我们的样本量排除了多重比较的校正，这些发现应该在更大的样本中重复。未来相关的额-纹状体回路功能变化的研究可以确定潜在的基于回路的干预目标。
Cross-sectional data suggest functional and anatomical disturbances in inferior and orbital frontal regions in bulimia nervosa (BN). Using longitudinal data, we investigated whether reduced cortical thickness (CT) in these regions arises early and persists over adolescence in BN, independent of symptom remission, and whether CT reductions are markers of BN symptoms. Thirty-three adolescent females with BN symptoms (BN or other specified feeding or eating disorder) and 28 healthy adolescents participated in this study. Anatomical magnetic resonance imaging and clinical data were acquired at three time points within 2-year intervals over adolescence with 31% average attrition between assessments. Using a region-of-interest approach, we assessed group differences in CT at baseline and over time, and tested whether between- and within-subject variations in CT were associated with the frequency of BN symptoms. Reduced CT in right inferior frontal gyrus persisted over adolescence in BN compared to healthy adolescents, even in those who achieved full or partial remission. Within the BN group, between-subject variations in CT in inferior and orbital frontal regions were inversely associated with specific BN symptoms, suggesting, on average over time, greater CT reductions in those with more frequent BN symptoms. Reduced CT in inferior frontal regions may contribute to illness persistence into adulthood. Reductions in the thickness of inferior and orbital frontal regions may be markers of specific BN symptoms. Since our sample size precluded correcting for multiple comparisons, these findings should be replicated in a larger sample. Future study of functional changes in associated fronto-striatal circuits could identify potential circuit-based intervention targets.
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DOI：
10.1016/j.jaac.2016.07.778
发表时间：
2016-11
影响因子：
13.3
作者：
Cyr, Marilyn;Wang, Zhishun;Tau, Gregory Z.;Zhao, Guihu;Friedl, Eve;Stefan, Mihaela;Terranova, Kate;Marsh, Rachel
通讯作者：
Marsh, Rachel
DOI：
10.1016/j.pnpbp.2016.06.005
发表时间：
2016-11-03
影响因子：
5.6
作者：
Depping, Malte S.;Wolf, Nadine D.;Wolf, Robert C.
通讯作者：
Wolf, Robert C.
影响因子：
5.7
作者：
Bernardoni, Fabio;King, Joseph A.;Ehrlich, Stefan
通讯作者：
Ehrlich, Stefan
影响因子：
5.7
作者：
Dale, AM;Fischl, B;Sereno, MI
通讯作者：
Sereno, MI
影响因子：
5.3
作者：
Fitzsimmons-Craft, Ellen E.;Ciao, Anna C.;Le Grange, Daniel
通讯作者：
Le Grange, Daniel