Reward-Based Spatial Learning in Teens With Bulimia Nervosa.
Reward-Based Spatial Learning in Teens With Bulimia Nervosa.
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DOI：
10.1016/j.jaac.2016.07.778
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发表时间：
2016-11
影响因子：
13.3
通讯作者：
Marsh, Rachel
中科院分区：
文献类型：
--
作者：
Cyr, Marilyn;Wang, Zhishun;Tau, Gregory Z.;Zhao, Guihu;Friedl, Eve;Stefan, Mihaela;Terranova, Kate;Marsh, Rachel
评估患有神经性贪食症（BN）的青少年女孩中涉及奖励空间学习的中脑边缘和额纹状体区的功能，这些功能可能涉及该疾病特征性适应不良行为的发展和维持。我们比较了27名BN少女与27名健康的年龄匹配的对照参与者在基于奖励的学习任务中的功能磁共振成像血氧水平依赖性反应，该任务要求学习使用额外的迷宫线索来导航虚拟8臂径向迷宫以找到隐藏的奖励。我们比较了与奖励空间学习相关的大脑激活模式与控制条件，其中奖励是意外的，因为它们被伪随机分配以实验性地阻止学习。两组都学会了在迷宫中寻找隐藏的奖励，但在额纹状体区和右前海马中检测到与迷宫导航和奖励处理相关的大脑活动的组间差异。与健康青少年不同，BN患者在迷宫导航过程中不参与右额下回，在接受意外奖励（对照条件）时激活右前海马，在接受预期奖励（学习条件）时停用左上级额回和右前海马。在对照组中，这些海马激活模式与暴饮暴食事件的频率显著相关。BN青少年在奖励空间学习过程中表现出海马前部和额纹状体功能异常。这些发现表明，在控制和奖励电路的不平衡可能会出现在BN的过程中早期。神经性贪食症青少年自我调节功能磁共振成像研究; https：//clinicaltrials.gov/ct2/show/NCT00345943; NCT 00345943。
To assess the functioning of mesolimbic and fronto-striatal areas involved in reward-based spatial learning in teenaged girls with bulimia nervosa (BN) that might be involved in the development and maintenance of maladaptive behaviors characteristic of the disorder. We compared functional magnetic resonance imaging blood oxygen level dependent response in 27 adolescent girls with BN to that of 27 healthy, age-matched control participants during a reward-based learning task that required learning to use extra-maze cues to navigate a virtual 8-arm radial maze to find hidden rewards. We compared groups in their patterns of brain activation associated with reward-based spatial learning versus a control condition in which rewards were unexpected because they were allotted pseudo-randomly to experimentally prevent learning. Both groups learned to navigate the maze to find hidden rewards, but group differences in brain activity associated with maze navigation and reward processing were detected in fronto-striatal regions and right anterior hippocampus. Unlike healthy adolescents, those with BN did not engage right inferior frontal gyrus during maze navigation, activated right anterior hippocampus during the receipt of unexpected rewards (control condition), and deactivated left superior frontal gyrus and right anterior hippocampus during expected reward receipt (learning condition). These patterns of hippocampal activation in the control condition were significantly associated with the frequency of binge-eating episodes. Adolescents with BN displayed abnormal functioning of anterior hippocampus and fronto-striatal regions during reward-based spatial learning. These findings suggest that an imbalance in control and reward circuits may arise early in the course of BN. An fMRI Study of Self-regulation in Adolescents With Bulimia Nervosa; https://clinicaltrials.gov/ct2/show/NCT00345943; NCT00345943.
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影响因子：
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作者：
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影响因子：
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影响因子：
6.7
作者：
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DOI：
10.1176/appi.ajp.2011.11010094
发表时间：
2011-11
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Marsh R;Horga G;Wang Z;Wang P;Klahr KW;Berner LA;Walsh BT;Peterson BS
通讯作者：
Peterson BS