Developmental trajectory of transmission speed in the human brain.

Developmental trajectory of transmission speed in the human brain.
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人脑传播速度的发展轨迹。

DOI:
10.1038/s41593-023-01272-0
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发表时间:
2023-04
影响因子:
25
通讯作者:
Hermes, Dora
Hermes, Dora
中科院分区:
医学1区
文献类型:
--
作者:
van Blooijs, Dorien;van den Boom, Max A. A.;van der Aar, Jaap F. F.;Huiskamp, Geertjan M. M.;Castegnaro, Giulio;Demuru, Matteo;Zweiphenning, Willemiek J. E. M.;van Eijsden, Pieter;Miller, Kai J. J.;Leijten, Frans S. S.;Hermes, Dora

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人类连接体的结构从童年到青春期一直发展到中年,但这些结构变化如何影响神经元信号传导的速度还没有得到很好的描述。在74名受试者中,我们测量了皮质-皮质诱发反应的潜伏期,并计算了其相应的传输速度。至少30年内传导延迟的减少表明神经元通讯的速度在成年后发展良好。本研究通过电脉冲和颅内记录绘制了人类大脑中传输速度的发展轨迹。研究人员发现,这些脉冲的传播速度至少在30岁以上。
The structure of the human connectome develops from childhood throughout adolescence to middle age, but how these structural changes affect the speed of neuronal signaling is not well described. In 74 subjects, we measured the latency of cortico-cortical evoked responses across association and U-fibers and calculated their corresponding transmission speeds. Decreases in conduction delays until at least 30 years show that the speed of neuronal communication develops well into adulthood. This study mapped the developmental trajectory of transmission speed in the human brain by using electrical pulses and intracranial recordings. The authors found that these pulses travel with increasing speeds up to at least the age of 30.
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