Self-reported walking pace, polygenic risk scores and risk of coronary artery disease in UK biobank.
Self-reported walking pace, polygenic risk scores and risk of coronary artery disease in UK biobank.
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英国生物样本库中自我报告的步行速度、多基因风险评分和冠状动脉疾病风险。
DOI：
10.1016/j.numecd.2022.08.021
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Zaccardi F
中科院分区：
文献类型：
--
作者：
Zaccardi F
多基因风险评分（PGS）和自我报告的步行速度都被证明可以预测心血管疾病;方法和结果我们估计了冠状动脉疾病（CAD）的10年绝对风险，调整了传统的风险因素，以及2006年3月至2021年2月期间英国生物库研究参与者9个PGS的C指数和自我报告的步行速度。在380，693例患者（54.8%女性）中，在中位数（第5，第95百分位数）11.9（8.3，13.4）年内，女性发生2，603例（1.2%）CAD事件，男性发生8，259例（4.8%）CAD事件。步行速度和遗传风险与CAD密切相关。高遗传风险（PGS前20%）的慢走者CAD的绝对10年风险最高：女性为2.72%（95%CI：2.30-3.13）;男性为9.60%（8.62-10.57）。慢速和快速步行者之间的风险差异在较高[女性1.26%（0.81-1.71）;男性3.63%（2.58-4.67）]比较低[分别为0.76%（0.59-0.93）和2.37%（1.96-2.78）]遗传风险更大。具有高遗传风险的快走者与具有中低遗传风险的慢走者（PGS的底部80%）相比具有相同（女性）或更高（男性）的风险。当添加到包含传统风险因素的模型中时，这两个因素分别提高了风险区分度;将它们结合起来导致最大的区分度：C指数为0.801（0.793-0.808）; 0.732（0.728-0.737）。结论自我报告的高遗传风险慢走者患冠心病的风险最大，确定潜在的重要人群进行干预。PGS和步行速度都有助于风险歧视。
Background and aimsBoth polygenic risk scores (PGS) and self-reported walking pace have been shown to predict cardiovascular disease; whether combining both factors produces greater risk differentiation is, however, unknown.Methods and resultsWe estimated the 10-year absolute risk of coronary artery disease (CAD), adjusted for traditional risk factors, and the C-index across nine PGS and self-reported walking pace in UK Biobank study participants between Mar/2006–Feb/2021. In 380,693 individuals (54.8% women), over a median (5th, 95th percentile) of 11.9 (8.3, 13.4) years, 2,603 (1.2%) CAD events occurred in women and 8,259 (4.8%) in men. Both walking pace and genetic risk were strongly associated with CAD. The absolute 10-year risk of CAD was highest in slow walkers at high genetic risk (top 20% of PGS): 2.72% (95% CI: 2.30–3.13) in women; 9.60% (8.62–10.57) in men. The risk difference between slow and brisk walkers was greater at higher [1.26% (0.81–1.71) in women; 3.63% (2.58–4.67) in men] than lower [0.76% (0.59–0.93) and 2.37% (1.96–2.78), respectively] genetic risk. Brisk walkers at high genetic risk had equivalent (women) or higher (men) risk than slow walkers at moderate-to-low genetic risk (bottom 80% of PGS). When added to a model containing traditional risk factors, both factors separately improved risk discrimination; combining them resulted in the greatest discrimination: C-index of 0.801 (0.793–0.808) in women; 0.732 (0.728–0.737) in men.ConclusionSelf-reported slow walkers at high genetic risk had the greatest risk of CAD, identifying a potentially important population for intervention. Both PGS and walking pace contributed to risk discrimination.
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影响因子：
5
作者：
Fry A;Littlejohns TJ;Sudlow C;Doherty N;Adamska L;Sprosen T;Collins R;Allen NE
通讯作者：
Allen NE
影响因子：
30.8
作者：
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作者：
Elliott, Joshua;Bodinier, Barbara;Tzoulaki, Ioanna
通讯作者：
Tzoulaki, Ioanna
影响因子：
8.3
作者：
Zaccardi, Francesco;Franks, Paul W.;Yates, Thomas
通讯作者：
Yates, Thomas