Functional heterogeneity of L3T4+ T cells in MRL-lpr/lpr mice. L3T4+ T cells suppress major histocompatibility complex-self-restricted L3T4+ T helper cell function in association with autoimmunity.
Functional heterogeneity of L3T4+ T cells in MRL-lpr/lpr mice. L3T4+ T cells suppress major histocompatibility complex-self-restricted L3T4+ T helper cell function in association with autoimmunity.
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MRL-LPR/LPR小鼠L3T4+ T细胞的功能异质性。 L3T4+ T细胞抑制了主要的组织相容性复合物限制的L3T4+ T辅助细胞功能与自身免疫相关。
DOI：
10.1084/jem.168.6.2165
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发表时间：
1988-12-01
影响因子：
15.3
通讯作者：
SHEARER, GM
中科院分区：
文献类型：
--
作者：
VIA, CS;SHEARER, GM
本研究证明在MR 1-lpr/lpr自身免疫小鼠中，通过L3 T4 + Th的MHC自限制功能的年龄依赖性丧失。这种缺陷不存在于年龄匹配的同源MRL-+/+脾细胞中，似乎是由于存在对L3 T4 + Th而不是对Lyt-2+ Th具有选择性的抑制细胞。令人惊讶的是，抑制细胞也是L3 T4 + T细胞，并且可以抑制同源MRL/+ L3 T4 + Th对MHC自限制性抗原的IL-2产生。这些数据支持L3 T4 + T细胞群内功能特化的想法。由于L3 T4+抑制细胞在自身免疫过程中检测到较晚，我们解释它们的存在不是自身免疫发展中的主要起始事件，而是作为一种补偿机制。此外，在小鼠移植物-vs.-中也报道了类似的L3 T4 + Th功能抑制。宿主模型的自身免疫，这表明抑制细胞代表了免疫调节机制，这是一个共同的特点，自身免疫。由于在两种自身免疫模型中都报道了B细胞的过度II类限制性Th活性，因此L3 T4+抑制细胞可能代表了下调这种过度Th活性的尝试。这些发现可能与人类自身免疫性疾病有关，如系统性红斑狼疮，其中B细胞过度活跃也与Th产生的IL-2减少有关。
The present study demonstrates in MRl-lpr/lpr autoimmune mice an age- dependent loss of MHC-self-restricted function by L3T4+ Th. This defect is not present in age-matched, congenic MRL-+/+ spleen cells and appears to be due to the presence of suppressor cells that are selective for L3T4+ Th and not for Lyt-2+ Th. Surprisingly, the suppressor cells are also L3T4+ T cells and can suppress the IL-2 production of congenic MRL/+ L3T4+ Th to MHC-self-restricted antigens. These data support the idea of functional specialization within the L3T4+ population of T cells. Because L3T4+ suppressor cells are detected late in the course of autoimmunity, we interpret their presence not as a primary initiating event in the development of autoimmunity, but rather as a compensatory mechanism. Additionally, similar suppression of L3T4+ Th function has also been reported in a murine graft-vs.-host model of autoimmunity, suggesting that the suppressor cells represent an immunoregulatory mechanism that is a common feature of autoimmunity. Since excessive class II-restricted Th activity for B cells has been reported for both models of autoimmunity, L3T4+ suppressor cells may represent an attempt to down regulate such excessive Th activity. These findings may be relevant to human autoimmune diseases, such as systemic lupus erythematosus, in which B cell hyperactivity is also associated with reduced IL-2 production by Th.
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影响因子：
64.8
作者：
LIEW, FY
通讯作者：
LIEW, FY
影响因子：
5.4
作者：
PFIZENMAIER, K;SCHEURICH, P;WAGNER, H
通讯作者：
WAGNER, H
DOI：
10.1084/jem.157.2.730
发表时间：
1983-02-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Prud'Homme GJ;Park CL;Fieser TM;Kofler R;Dixon FJ;Theofilopoulos AN
通讯作者：
Theofilopoulos AN
自身免疫性鼠菌株中T细胞功能的分析。生产缺陷和对白介素2的反应性。
影响因子：
15.3
作者：
Altman, A;Theofilopoulos, A N;Weiner, R;Katz, D H;Dixon, F J
通讯作者：
Dixon, F J
影响因子：
8.7
作者：
CANTOR, H;BOYSE, EA
通讯作者：
BOYSE, EA