The medial habenula: still neglected.
The medial habenula: still neglected.
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DOI：
10.3389/fnhum.2013.00931
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发表时间：
2013
影响因子：
2.9
通讯作者：
Salas R
中科院分区：
文献类型：
--
作者：
Viswanath H;Carter AQ;Baldwin PR;Molfese DL;Salas R
缰是位于间脑背端的一个小的双侧脑结构。这种结构向多巴胺能纹状体发送投射，并接收来自边缘前脑的输入，使缰状体成为这些大脑区域之间串音的独特调制器。尽管在七八十年代人们对habenula有浓厚的兴趣（Herkenham and Nauta,; Beckstead,; Beckstead et al.,; Herkenham and Nauta,; caldecot - hazard et al.,），但由于缺乏明确的功能作用，人们对habenula的兴趣逐渐减弱。松本和Hikosaka的开创性研究表明，侧缰状核是猴子负奖励的一个预测因素，在此之后，缰状核又重新引起了科学界的兴趣。Matsumoto和Hikosaka证明，当猴子没有得到预期的果汁奖励时，缰状神经元的放电会增加（Matsumoto和Hikosaka，）。研究表明，habenular活性的增加通过gaba能机制使Rostromedial Tegmental Nucleus （RMTg）中的多巴胺能细胞失活（Jhou et al.,）。其他研究将缰状核的活动与血清素和去甲肾上腺素的调节联系起来，表明缰状核调节了多个大脑系统（Strecker和Rosengren，； Amat等）。这些发现引发了一系列新的研究，这些研究重新将注意力集中在外侧系带和这个小大脑结构的重要性上（Bianco和Wilson，； Jhou等人，；Matsumoto和Hikosaka，； Sartorius等人，；Savitz等人，）。最近，Geisler和Trimble回顾了这一新的兴趣：外侧缰：不再被忽视（Geisler和Trimble，）。虽然侧束（LHb）已被广泛研究，但在解剖学和组织化学上不同的内侧束（MHb）仍未得到充分研究。这篇简短的综述认为MHb在功能上很重要，应该进行更积极的研究。
The habenula is a small, bilateral brain structure located at the dorsal end of the diencephalon. This structure sends projections to the dopaminergic striatum and receives inputs from the limbic forebrain, making the habenula a unique modulator of cross-talk between these brain regions. Despite strong interest in the habenula during the seventies and eighties (Herkenham and Nauta,; Beckstead,; Beckstead et al.,; Herkenham and Nauta,; Caldecott-Hazard et al.,), interest waned due to lack of a clearly identifiable functional role. Following Matsumoto and Hikosaka's seminal work on the lateral habenula as a predictor of negative reward in monkeys, the habenula has undergone a resurgence of scientific interest. Matsumoto and Hikosaka demonstrated an increase in habenular neuron firing when monkeys did not receive an expected juice reward (Matsumoto and Hikosaka,). Studies have shown that increased habenular activity inactivates dopaminergic cells in the Rostromedial Tegmental Nucleus (RMTg) through GABAergic mechanisms (Jhou et al.,). Additional studies link habenular activity to the regulation of serotonin and norepinephrine, suggesting the habenula modulates multiple brain systems (Strecker and Rosengren,; Amat et al.,). These discoveries ushered in a series of new studies that have refocused attention on the lateral habenula and the importance of this small brain structure (Bianco and Wilson,; Jhou et al.,; Matsumoto and Hikosaka,; Sartorius et al.,; Savitz et al.,). Recently, Geisler and Trimble reviewed this renewed interest in: The Lateral Habenula: No Longer Neglected (Geisler and Trimble,). While the lateral habenula (LHb) has been extensively studied, the anatomically and histochemically distinct medial habenula (MHb) remains largely understudied. This short review argues that the MHb is functionally important and should be studied more aggressively.
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缰核：脊椎动物大脑中保守的不对称中继站。
DOI：
10.1098/rstb.2008.0213
发表时间：
2009-04-12
影响因子：
6.3
作者：
Bianco, Isaac H.;Wilson, Stephen W.
通讯作者：
Wilson, Stephen W.
影响因子：
2.5
作者：
Balcita-Pedicino, Judith Joyce;Omelchenko, Natalia;Bell, Roland;Sesack, Susan R.
通讯作者：
Sesack, Susan R.
影响因子：
5.6
作者：
Ellison, G
通讯作者：
Ellison, G
影响因子：
2.5
作者：
BECKSTEAD, RM
通讯作者：
BECKSTEAD, RM
影响因子：
2.9
作者：
Carlson, J;Noguchi, K;Ellison, G
通讯作者：
Ellison, G