ZFAS1: a novel tumor-related long non-coding RNA.
ZFAS1: a novel tumor-related long non-coding RNA.
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DOI：
10.1186/s12935-018-0623-y
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发表时间：
2018
影响因子：
5.8
通讯作者：
Sun M
中科院分区：
文献类型：
--
作者：
Dong D;Mu Z;Zhao C;Sun M
长链非编码RNA（longnon-codingRNA，lncRNA）是一类长度超过200个核苷酸，不能翻译成蛋白质的RNA。多项研究表明，lncRNA参与各种细胞过程，包括增殖、分化、细胞死亡和转移。此外，在人类肿瘤中已经发现lncRNA的异常表达，其中它们作为癌基因或肿瘤抑制基因起作用。在众多的lncRNA中，我们关注ZNFX 1反义RNA 1（ZFAS 1），ZFAS 1是一种众所周知的lncRNA，其在多种肿瘤中异常过表达，包括黑色素瘤、食管鳞状细胞癌、非小细胞肺癌、胃癌、结肠癌和肝细胞癌，其中ZFAS 1作为癌基因发挥作用。相反，ZFAS 1在乳腺癌中表达下调，可能起肿瘤抑制基因的作用。在这篇综述中，我们提供了一个关于ZFAS 1在人类癌症中的作用和潜在临床应用的现有证据的概述。
Long non-coding RNAs (lncRNA) are classified as a kind of RNA, which are longer than 200 nucleotides in length and cannot be translated into proteins. Multiple studies have demonstrated that lncRNAs are involved in various cellular processes, including proliferation, differentiation, cell death, and metastasis. In addition, aberrant expression of lncRNAs has been discovered in human tumors, where they function as either oncogenes or tumor suppressor genes. Among numerous lncRNAs, we focus on ZNFX1 antisense RNA 1 (ZFAS1), a well-known lncRNA that is aberrant overexpression in various tumors, including melanoma, esophageal squamous cell carcinoma, non-small cell lung cancer, gastric cancer, colon cancer, and Hepatocellular carcinoma, in which it functions as oncogene. In contrast, ZFAS1 is downregulated in breast cancer, which may function as tumor suppressor gene. In this review, we provide an overview of current evidence concerning the role and potential clinical utilities of ZFAS1 in human cancers.
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影响因子：
7
作者：
Harrow J;Frankish A;Gonzalez JM;Tapanari E;Diekhans M;Kokocinski F;Aken BL;Barrell D;Zadissa A;Searle S;Barnes I;Bignell A;Boychenko V;Hunt T;Kay M;Mukherjee G;Rajan J;Despacio-Reyes G;Saunders G;Steward C;Harte R;Lin M;Howald C;Tanzer A;Derrien T;Chrast J;Walters N;Balasubramanian S;Pei B;Tress M;Rodriguez JM;Ezkurdia I;van Baren J;Brent M;Haussler D;Kellis M;Valencia A;Reymond A;Gerstein M;Guigó R;Hubbard TJ
通讯作者：
Hubbard TJ
影响因子：
4.1
作者：
Fang, Changyi;Zan, Jianbao;Yan, Dongwang
通讯作者：
Yan, Dongwang
影响因子：
4.5
作者：
Askarian-Amiri, Marjan E.;Crawford, Joanna;Mattick, John S.
通讯作者：
Mattick, John S.
影响因子：
--
作者：
Lv, Qiao-Li;Chen, Shu-Hui;Zhou, Hong-Hao
通讯作者：
Zhou, Hong-Hao
影响因子：
7.5
作者：
Gao, Kai;Ji, Zhiwu;Shao, Lianbin
通讯作者：
Shao, Lianbin