Two-photon polymerization of microneedles for transdermal drug delivery.
Two-photon polymerization of microneedles for transdermal drug delivery.
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DOI：
10.1517/17425241003628171
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发表时间：
2010-04
影响因子：
6.6
通讯作者：
Narayan RJ
中科院分区：
文献类型：
--
作者：
Gittard SD;Ovsianikov A;Chichkov BN;Doraiswamy A;Narayan RJ
微针是用于基于蛋白质的药理学试剂和基于核酸的药理学试剂的经皮递送的小规模装置;然而，使用常规的基于微电子的技术制备的微针具有几个缺点，这限制了这些装置向广泛临床应用的转化。双光子聚合是一种基于激光的快速成型技术，最近已被用于直接制造具有各种几何形状的中空微针。此外，一个间接的快速成型方法，涉及双光子聚合和聚二甲基硅氧烷微成型已被用于制造固体微针具有特殊的机械性能。在这篇综述中，使用双光子聚合制备面内和面外空心微针阵列的描述。本文还综述了双光子聚合-微成型技术在固体微针制备中的应用。此外，还讨论了具有抗菌性能的微针的制造;抗菌微针可以降低与穿过角质层的通道形成相关的感染风险。预计在未来几年中，使用双光子聚合以及双光子聚合-微成型来制造微针和其他微结构化药物递送装置将增加。
Microneedles are small-scale devices that are finding use for transdermal delivery of protein-based pharmacologic agents and nucleic acid-based pharmacologic agents; however, microneedles prepared using conventional microelectronics-based technologies have several shortcomings, which have limited translation of these devices into widespread clinical use. Two photon polymerization is a laser-based rapid prototyping technique that has been recently used for direct fabrication of hollow microneedles with a wide variety of geometries. In addition, an indirect rapid prototyping method that involves two photon polymerization and polydimethyl siloxane micromolding has been used for fabrication of solid microneedles with exceptional mechanical properties. In this review, the use of two photon polymerization for fabricating in-plane and out-of-plane hollow microneedle arrays is described. The use of two photon polymerization-micromolding for fabrication of solid microneedles is also reviewed. In addition, fabrication of microneedles with antimicrobial properties is discussed; antimicrobial microneedles may reduce the risk of infection associated with formation of channels through the stratum corneum. It is anticipated that the use of two photon polymerization as well as two photon polymerization-micromolding for fabrication of microneedles and other microstructured drug delivery devices will increase over the coming years.
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