The nasal and gut microbiome in Parkinson's disease and idiopathic rapid eye movement sleep behavior disorder.
The nasal and gut microbiome in Parkinson's disease and idiopathic rapid eye movement sleep behavior disorder.
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DOI：
10.1002/mds.27105
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发表时间：
2018-01
期刊：
影响因子：
--
通讯作者：
Wilmes P
中科院分区：
文献类型：
--
作者：
Heintz-Buschart A;Pandey U;Wicke T;Sixel-Döring F;Janzen A;Sittig-Wiegand E;Trenkwalder C;Oertel WH;Mollenhauer B;Wilmes P
越来越多的证据将肠道微生物群与帕金森病（PD）的发病和/或表型联系起来。PD患者中特定细菌分类群丰度的差异已有报道。然而，尚不清楚这些差异是否可以在高风险个体中观察到，例如，患有特发性快速眼动睡眠行为障碍，α-突触核蛋白聚集障碍（包括PD）的前驱状态。比较患有特发性快速眼动睡眠行为障碍、显性PD的受试者和健康个体的仔细保存的鼻洗液和粪便样本中的微生物群。通过16 S和18 S核糖体RNA扩增子测序评估了来自76名PD患者、21名特发性快速眼动睡眠行为障碍患者和78名健康对照的速冻粪便和鼻洗液样本的微生物群。分析了与人口统计学、临床参数（包括非运动症状）和样本处理相关的70个变量与微生物组变异性的关系，并进行了受控差异分析。在PD中观察到不同丰度的肠道微生物，如阿克曼氏菌，但在鼻微生物群中没有强烈的差异。与健康对照相比，PD中80%的差异肠道微生物在特发性快速眼动睡眠行为障碍中显示出相似的趋势，例如，Anaerotruncus和几种拟杆菌属，并与非运动症状相关。选择样品的宏基因组测序使得能够重建迄今为止未表征的差异丰富的生物体的基因组。我们的研究揭示了与健康对照相比，PD及其前驱症状特发性快速眼动睡眠行为障碍中肠道微生物类群的差异丰度，并强调了宏基因组学识别和表征微生物类群的潜力，这些微生物类群在PD和/或特发性快速眼动睡眠行为障碍中富集或耗尽。© 2017作者。出版社：Wiley Periodicals，Inc.国际帕金森和运动障碍协会（International Parkinson and Movement Disorder Society）
Increasing evidence connects the gut microbiota and the onset and/or phenotype of Parkinson's disease (PD). Differences in the abundances of specific bacterial taxa have been reported in PD patients. It is, however, unknown whether these differences can be observed in individuals at high risk, for example, with idiopathic rapid eye movement sleep behavior disorder, a prodromal condition of α‐synuclein aggregation disorders including PD. To compare microbiota in carefully preserved nasal wash and stool samples of subjects with idiopathic rapid eye movement sleep behavior disorder, manifest PD, and healthy individuals. Microbiota of flash‐frozen stool and nasal wash samples from 76 PD patients, 21 idiopathic rapid eye movement sleep behavior disorder patients, and 78 healthy controls were assessed by 16S and 18S ribosomal RNA amplicon sequencing. Seventy variables, related to demographics, clinical parameters including nonmotor symptoms, and sample processing, were analyzed in relation to microbiome variability and controlled differential analyses were performed. Differentially abundant gut microbes, such as Akkermansia, were observed in PD, but no strong differences in nasal microbiota. Eighty percent of the differential gut microbes in PD versus healthy controls showed similar trends in idiopathic rapid eye movement sleep behavior disorder, for example, Anaerotruncus and several Bacteroides spp., and correlated with nonmotor symptoms. Metagenomic sequencing of select samples enabled the reconstruction of genomes of so far uncharacterized differentially abundant organisms. Our study reveals differential abundances of gut microbial taxa in PD and its prodrome idiopathic rapid eye movement sleep behavior disorder in comparison to the healthy controls, and highlights the potential of metagenomics to identify and characterize microbial taxa, which are enriched or depleted in PD and/or idiopathic rapid eye movement sleep behavior disorder. © 2017 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.
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影响因子：
3.7
作者：
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通讯作者：
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