Prospective Case-Control Study of Cardiovascular Abnormalities 6 Months Following Mild COVID-19 in Healthcare Workers.
Prospective Case-Control Study of Cardiovascular Abnormalities 6 Months Following Mild COVID-19 in Healthcare Workers.
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DOI：
10.1016/j.jcmg.2021.04.011
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发表时间：
2021-11
期刊：
影响因子：
--
通讯作者：
COVIDsortium Investigators
中科院分区：
文献类型：
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作者：
Joy G;Artico J;Kurdi H;Seraphim A;Lau C;Thornton GD;Oliveira MF;Adam RD;Aziminia N;Menacho K;Chacko L;Brown JT;Patel RK;Shiwani H;Bhuva A;Augusto JB;Andiapen M;McKnight A;Noursadeghi M;Pierce I;Evain T;Captur G;Davies RH;Greenwood JP;Fontana M;Kellman P;Schelbert EB;Treibel TA;Manisty C;Moon JC;COVIDsortium Investigators
本研究的目的是检测轻度严重急性呼吸综合征-冠状病毒-2感染后的心血管变化。人们担心2019年的轻度冠状病毒病可能会导致心肌和血管疾病。参与者是从COVID-19招募的，COVID-19是一项3医院前瞻性研究，共有731名医护人员参加，他们在4个月内接受了第一波每周症状，聚合酶链反应和血清学评估，血清转换率为21.5%（n = 157）。在感染后6个月，招募74名血清阳性和75名年龄、性别和种族匹配的血清阴性对照受试者进行心血管表型分析（综合体模校准的心血管磁共振和血液生物标志物）。分析是设盲的，使用客观的人工智能分析（如可用）。共招募了149例受试者（平均年龄37岁，范围18 - 63岁，58%为女性）。血清阳性感染为轻度病例定义、非病例定义和无症状疾病，分别为45例（61%）、18例（24%）和11例（15%），1人住院（2天）。在血清阳性组和血清阴性组之间，心脏结构（左心室容积、质量、心房面积）、功能（射血分数、总体纵向缩短、主动脉扩张性）、组织表征（T1、T2、细胞外容积分数标测、晚期钆增强）或生物标志物（肌钙蛋白、N末端B型利钠肽前体）无差异。通过75例血清阴性定义为异常（平均值的2个SD，例如，射血分数<54%，间隔T1 > 1，072 ms，间隔T2 >52.4 ms），个体存在射血分数降低等异常（n = 2，最小50%），T1抬高（n = 6），T2抬高（n = 9），晚期钆增强（n = 13，心肌的中位数1%，最大值5%），生物标志物升高（4例肌钙蛋白临界升高;所有N末端B型利钠肽前体正常）。这些在血清反应阳性和血清反应阴性个体之间平均分布。心血管异常在轻度严重急性呼吸综合征-冠状病毒-2感染后6个月血清阳性与血清阴性的健康劳动力代表性个体中并不常见。
The purpose of this study was to detect cardiovascular changes after mild severe acute respiratory syndrome-coronavirus-2 infection. Concern exists that mild coronavirus disease 2019 may cause myocardial and vascular disease. Participants were recruited from COVIDsortium, a 3-hospital prospective study of 731 health care workers who underwent first-wave weekly symptom, polymerase chain reaction, and serology assessment over 4 months, with seroconversion in 21.5% (n = 157). At 6 months post-infection, 74 seropositive and 75 age-, sex-, and ethnicity-matched seronegative control subjects were recruited for cardiovascular phenotyping (comprehensive phantom-calibrated cardiovascular magnetic resonance and blood biomarkers). Analysis was blinded, using objective artificial intelligence analytics where available. A total of 149 subjects (mean age 37 years, range 18 to 63 years, 58% women) were recruited. Seropositive infections had been mild with case definition, noncase definition, and asymptomatic disease in 45 (61%), 18 (24%), and 11 (15%), respectively, with 1 person hospitalized (for 2 days). Between seropositive and seronegative groups, there were no differences in cardiac structure (left ventricular volumes, mass, atrial area), function (ejection fraction, global longitudinal shortening, aortic distensibility), tissue characterization (T1, T2, extracellular volume fraction mapping, late gadolinium enhancement) or biomarkers (troponin, N-terminal pro–B-type natriuretic peptide). With abnormal defined by the 75 seronegatives (2 SDs from mean, e.g., ejection fraction <54%, septal T1 >1,072 ms, septal T2 >52.4 ms), individuals had abnormalities including reduced ejection fraction (n = 2, minimum 50%), T1 elevation (n = 6), T2 elevation (n = 9), late gadolinium enhancement (n = 13, median 1%, max 5% of myocardium), biomarker elevation (borderline troponin elevation in 4; all N-terminal pro–B-type natriuretic peptide normal). These were distributed equally between seropositive and seronegative individuals. Cardiovascular abnormalities are no more common in seropositive versus seronegative otherwise healthy, workforce representative individuals 6 months post–mild severe acute respiratory syndrome-coronavirus-2 infection.
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DOI：
10.1186/s12968-017-0389-8
发表时间：
2017-10-09
期刊：
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
影响因子：
--
作者：
Messroghli DR;Moon JC;Ferreira VM;Grosse-Wortmann L;He T;Kellman P;Mascherbauer J;Nezafat R;Salerno M;Schelbert EB;Taylor AJ;Thompson R;Ugander M;van Heeswijk RB;Friedrich MG
通讯作者：
Friedrich MG
DOI：
10.1186/s12968-016-0280-z
发表时间：
2016-09-22
期刊：
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
影响因子：
--
作者：
Captur G;Gatehouse P;Keenan KE;Heslinga FG;Bruehl R;Prothmann M;Graves MJ;Eames RJ;Torlasco C;Benedetti G;Donovan J;Ittermann B;Boubertakh R;Bathgate A;Royet C;Pang W;Nezafat R;Salerno M;Kellman P;Moon JC
通讯作者：
Moon JC
影响因子：
24
作者：
Puntmann, Valentina O.;Carerj, M. Ludovica;Nagel, Eike
通讯作者：
Nagel, Eike
DOI：
10.1016/j.jcmg.2020.10.023
发表时间：
2021-03
期刊：
JACC. Cardiovascular imaging
影响因子：
--
作者：
Brito D;Meester S;Yanamala N;Patel HB;Balcik BJ;Casaclang-Verzosa G;Seetharam K;Riveros D;Beto RJ 2nd;Balla S;Monseau AJ;Sengupta PP
通讯作者：
Sengupta PP
影响因子：
6.4
作者：
Captur, Gabriella;Bhandari, Abhiyan;Moon, James C.
通讯作者：
Moon, James C.