High Prevalence of Pericardial Involvement in College Student Athletes Recovering From COVID-19.
High Prevalence of Pericardial Involvement in College Student Athletes Recovering From COVID-19.
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从COVID-19中恢复的大学生运动员中心包受累的高患病率。
DOI：
10.1016/j.jcmg.2020.10.023
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Sengupta PP
中科院分区：
文献类型：
--
作者：
Brito D;Meester S;Yanamala N;Patel HB;Balcik BJ;Casaclang-Verzosa G;Seetharam K;Riveros D;Beto RJ 2nd;Balla S;Monseau AJ;Sengupta PP
本研究旨在探讨2020年7月患有2019年无并发症冠状病毒病（COVID-19）回到大学校园的学生运动员的心脏异常谱。关于患有轻度或无症状COVID-19的年轻人心血管疾病的信息有限。对54名平均年龄19岁，85%为男性的连续学生运动员进行超声心动图筛查，结果均为上呼吸道逆转录聚合酶链反应鼻拭子试验阳性或抗严重急性呼吸综合征冠状病毒2型免疫球蛋白G抗体阳性。48例（89%）受试者进行序贯心脏磁共振成像。共有16名（30%）运动员无症状，36名（66%）和2名（4%）运动员分别报告了轻度和中度COVID-19相关症状。在完成两项影像学检查的48名运动员中，27人（56.3%）发现异常。其中包括19例（39.5%）晚期心包增强伴心包积液的运动员。在心包增强的个体中，6例（12.5%）整体纵向应变降低和/或原生T1增加。1例患者表现出心肌增强，另外7例（14.6%）患者还发现左室射血分数降低或整体纵向应变降低，伴有或不伴有原生T1值升高。所有受试者的T2表现均正常，未发现心肌炎症的特异性影像学特征。左心室区域应变的分层聚类鉴定出3种独特的心肌外膜表型，这些表型与心脏磁共振结果有显著相关性（p = 0.03）。从COVID-19感染中恢复过来的健康大学运动员中，超过三分之一的人表现出心包炎症消退的影像学特征。虽然发现了心肌结构和功能的细微变化，但没有运动员表现出特定的影像学特征来提示持续的心肌炎。需要进一步的研究来了解这些异常在无并发症的COVID-19中的临床意义和长期演变。
This study sought to explore the spectrum of cardiac abnormalities in student athletes who returned to university campus in July 2020 with uncomplicated coronavirus disease 2019 (COVID-19). There is limited information on cardiovascular involvement in young individuals with mild or asymptomatic COVID-19. Screening echocardiograms were performed in 54 consecutive student athletes (mean age 19 years; 85% male) who had positive results of reverse transcription polymerase chain reaction nasal swab testing of the upper respiratory tract or immunoglobulin G antibodies against severe acute respiratory syndrome coronavirus type 2. Sequential cardiac magnetic resonance imaging was performed in 48 (89%) subjects. A total of 16 (30%) athletes were asymptomatic, whereas 36 (66%) and 2 (4%) athletes reported mild and moderate COVID-19 related symptoms, respectively. For the 48 athletes completing both imaging studies, abnormal findings were identified in 27 (56.3%) individuals. This included 19 (39.5%) athletes with pericardial late enhancements with associated pericardial effusion. Of the individuals with pericardial enhancements, 6 (12.5%) had reduced global longitudinal strain and/or an increased native T1. One patient showed myocardial enhancement, and reduced left ventricular ejection fraction or reduced global longitudinal strain with or without increased native T1 values was also identified in an additional 7 (14.6%) individuals. Native T2 findings were normal in all subjects, and no specific imaging features of myocardial inflammation were identified. Hierarchical clustering of left ventricular regional strain identified 3 unique myopericardial phenotypes that showed significant association with the cardiac magnetic resonance findings (p = 0.03). More than 1 in 3 previously healthy college athletes recovering from COVID-19 infection showed imaging features of a resolving pericardial inflammation. Although subtle changes in myocardial structure and function were identified, no athlete showed specific imaging features to suggest an ongoing myocarditis. Further studies are needed to understand the clinical implications and long-term evolution of these abnormalities in uncomplicated COVID-19.
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DOI：
10.1186/s12968-017-0389-8
发表时间：
2017-10-09
期刊：
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
影响因子：
--
作者：
Messroghli DR;Moon JC;Ferreira VM;Grosse-Wortmann L;He T;Kellman P;Mascherbauer J;Nezafat R;Salerno M;Schelbert EB;Taylor AJ;Thompson R;Ugander M;van Heeswijk RB;Friedrich MG
通讯作者：
Friedrich MG
影响因子：
7.5
作者：
McDiarmid, Adam K.;Swoboda, Peter P.;Plein, Sven
通讯作者：
Plein, Sven
影响因子：
6.2
作者：
Lang, Roberto M.;Badano, Luigi P.;Voigt, Jens-Uwe
通讯作者：
Voigt, Jens-Uwe
影响因子：
2.1
作者：
Leitman, Marina;Vered, Zvi;Copel, Laurian
通讯作者：
Copel, Laurian
影响因子：
158.5
作者：
Ackermann, Maximilian;Verleden, Stijn E.;Jonigk, Danny
通讯作者：
Jonigk, Danny