Expansion of the eukaryotic proteome by alternative splicing.
Expansion of the eukaryotic proteome by alternative splicing.
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作者：
要完成生成和维持一个有生命、有呼吸、有时还有思考的有机体的复杂过程，所需的组件集合是惊人的复杂。所有的零件都是从哪里来的？早期的估计表明，组成哺乳动物需要大约10万个基因;然而，实际数量不到四分之一，几乎是芽殖酵母基因数量的四倍。现在很清楚，“缺失”的信息在很大程度上是由选择性剪接提供的，选择性剪接是多个不同功能的信使RNA和蛋白质可以从单个基因合成的过程。
The collection of components required to carry out the intricate processes involved in generating and maintaining a living, breathing and, sometimes, thinking organism is staggeringly complex. Where do all of the parts come from? Early estimates stated that about 100,000 genes would be required to make up a mammal; however, the actual number is less than one-quarter of that, barely four times the number of genes in budding yeast. It is now clear that the ‘missing’ information is in large part provided by alternative splicing, the process by which multiple different functional messenger RNAs, and therefore proteins, can be synthesized from a single gene.
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影响因子：
64.5
作者：
Graveley, BR
通讯作者：
Graveley, BR
影响因子：
16
作者：
Blanchette, Marco;Green, Richard E.;Rio, Donald C.
通讯作者：
Rio, Donald C.
DOI：
10.1073/pnas.151268698
发表时间：
2001-08-14
影响因子：
11.1
作者：
Dorn, R;Reuter, G;Loewendorf, A
通讯作者：
Loewendorf, A
影响因子：
64.5
作者：
EARLY, P;ROGERS, J;HOOD, L
通讯作者：
HOOD, L
可变窗口绑定，用于相互排斥的替代剪接。
影响因子：
12.3
作者：
Anastassiou, Dimitris;Liu, Hairuo;Varadan, Vinay
通讯作者：
Varadan, Vinay