The recent advances in scaffolds for integrated periodontal regeneration.
The recent advances in scaffolds for integrated periodontal regeneration.
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DOI：
10.1016/j.bioactmat.2021.03.012
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发表时间：
2021-10
影响因子：
18.9
通讯作者：
Lee CH
中科院分区：
文献类型：
--
作者：
Woo HN;Cho YJ;Tarafder S;Lee CH
牙周组织是围绕和支撑牙齿的多个组织的集成功能单位，包括但不限于牙骨质（CM）、牙周膜（PDL）和牙槽骨（AB）。慢性牙周病会破坏牙周组织，导致牙齿脱落。为了支持牙周病牙齿的治疗，各种生物材料已被应用于引导组织再生（GTR）中的接触抑制膜，这是当前牙科诊所的黄金标准。近年来，各种生物材料被制备成组织工程支架的形式，以促进受损牙周组织的再生。从支持单一类型牙周组织愈合的物理基质到指导牙周组织综合再生的多相/生物活性支架系统，支架制造技术在过去几年中不断涌现。本综述涵盖了用于牙周组织再生的支架开发的最新进展及其体外和体内功效测试。还讨论了用于牙周组织再生的不同生物材料和设计参数的优缺点，包括未来的前景。牙周病是牙齿脱落的主要原因，目前的治疗方法存在局限性。最近出现了生物材料支架引导的牙周组织再生。本综述讨论了用于多种牙周组织整合再生的生物活性支架的最新进展。还讨论了突出的局限性和未来的前景。
The periodontium is an integrated, functional unit of multiple tissues surrounding and supporting the tooth, including but not limited to cementum (CM), periodontal ligament (PDL) and alveolar bone (AB). Periodontal tissues can be destructed by chronic periodontal disease, which can lead to tooth loss. In support of the treatment for periodontally diseased tooth, various biomaterials have been applied starting as a contact inhibition membrane in the guided tissue regeneration (GTR) that is the current gold standard in dental clinic. Recently, various biomaterials have been prepared in a form of tissue engineering scaffold to facilitate the regeneration of damaged periodontal tissues. From a physical substrate to support healing of a single type of periodontal tissue to multi-phase/bioactive scaffold system to guide an integrated regeneration of periodontium, technologies for scaffold fabrication have emerged in last years. This review covers the recent advancements in development of scaffolds designed for periodontal tissue regeneration and their efficacy tested in vitro and in vivo. Pros and Cons of different biomaterials and design parameters implemented for periodontal tissue regeneration are also discussed, including future perspectives. Periodontal diseases are a major cause of tooth loss and the current treatment suffers from limitations. Biomaterial scaffold-guided regeneration of periodontal tissues have recently emerged. This review addresses the recent advance in bioactive scaffold for integrated regeneration of multiple periodontal tissues. The outstanding limitations and future perspectives are also discussed.
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影响因子：
4.3
作者：
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通讯作者：
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影响因子：
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作者：
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DOI：
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发表时间：
2018-10
期刊：
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影响因子：
--
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通讯作者：
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