Sentinels at the wall: epithelial-derived cytokines serve as triggers of upper airway type 2 inflammation.
Sentinels at the wall: epithelial-derived cytokines serve as triggers of upper airway type 2 inflammation.
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DOI：
10.1002/alr.22206
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发表时间：
2019-01
影响因子：
6.4
通讯作者：
Cohen NA
中科院分区：
文献类型：
--
作者：
Patel NN;Kohanski MA;Maina IW;Workman AD;Herbert DR;Cohen NA
Recent evidence is demonstrating an expanding role of respiratory epithelial cells in immune surveillance and modulation. Studies are focusing on the earliest events that link epithelial injury to down-stream inflammatory responses. Cytokines produced by and released from respiratory epithelial cells are among these early trigger signals. Epithelial-derived cytokines, namely thymic stromal lymphopoietin (TSLP), IL-25, and IL-33, have come to the forefront of recent investigation. Each of these three cytokines has been implicated in chronic rhinosinusitis (CRS), asthma, and atopy. Here we review studies elucidating the roles of epithelial-derived cytokines in the pathobiology of upper airway disease, with particular emphasis on type-2 inflammatory conditions.
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DOI：
10.1084/jem.20062211
发表时间：
2007-02-19
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
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通讯作者：
Delespesse G
影响因子：
64.8
作者：
Gerbe F;Sidot E;Smyth DJ;Ohmoto M;Matsumoto I;Dardalhon V;Cesses P;Garnier L;Pouzolles M;Brulin B;Bruschi M;Harcus Y;Zimmermann VS;Taylor N;Maizels RM;Jay P
通讯作者：
Jay P
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DOI：
10.1126/science.aaf1648
发表时间：
2016-03-18
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
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通讯作者：
Garrett WS
影响因子：
6.4
作者：
Barham, Henry P.;Cooper, Sarah E.;Anderson, Catherine B.;Tizzano, Marco;Kingdom, Todd T.;Finger, Tom E.;Kinnamon, Sue C.;Ramakrishnan, Vijay R.
通讯作者：
Ramakrishnan, Vijay R.
局部 IL-25 导致鼻息肉中 Th2 偏向的炎症特征。
影响因子：
12.4
作者：
Hong, H-Y.;Chen, F-H.;Shi, J-B.
通讯作者：
Shi, J-B.