Spatiotemporal invasion dynamics of SARS-CoV-2 lineage B.1.1.7 emergence.
Spatiotemporal invasion dynamics of SARS-CoV-2 lineage B.1.1.7 emergence.
复制标题
DOI：
10.1126/science.abj0113
复制
发表时间：
2021-08-20
期刊：
影响因子：
56.9
通讯作者：
Pybus, Oliver G.
中科院分区：
文献类型：
--
作者：
Kraemer, Moritz U. G.;Hill, Verity;Ruis, Christopher;Dellicour, Simon;Bajaj, Sumali;McCrone, John T.;Baele, Guy;Parag, Kris V.;Battle, Anya Lindstrom;Gutierrez, Bernardo;Jackson, Ben;Colquhoun, Rachel;O'Toole, Aine;Klein, Brennan;Vespignani, Alessandro;Volz, Erik;Faria, Nuno R.;Aanensen, David M.;Loman, Nicholas J.;du Plessis, Louis;Cauchemez, Simon;Rambaut, Andrew;Scarpino, Samuel V.;Pybus, Oliver G.
严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）的B.1.1.7谱系在全球范围内引起了快速蔓延的疫情。本质上，这种变体比其前身具有更大的传播性，但这种能力在某些情况下被人类行为和局部免疫力的结合放大到悲剧效果。哪些外在因素有助于或阻碍变异的快速传播？Kraemer等人探索了B.1.1.7的入侵动力学。从它在英国肯特的原产地到它在全国各地的异质传播，都有很好的细节。移动的手机和病毒数据（包括17,000多个基因组）的组合显示了不同的传播阶段与移动强度和封锁时间的关系。随着当地疫情的增长，来自伦敦疫区的输入变得不那么重要了。患有B.1.1.7。如果在一年中的不同时间出现，其影响可能会有所不同。-CA解开导致病毒变异快速传播的因素对于理解其流行病学后果至关重要。了解严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）变异出现的原因和后果对于大流行控制至关重要，但难以实现，因为它们是在可变的人类行为和免疫力的背景下出现的。我们通过联合分析英国人类流动性、病毒基因组和基于社区的聚合酶链反应数据，研究了谱系B.1.1.7的空间入侵动态。我们确定了一个多阶段的空间入侵过程中，早期B.1.1.7的增长率与流动性和不对称的血统出口从一个占主导地位的源位置，增强了B.1.1.7的增加的内在传递性的影响。我们进一步探讨了B.1.1.7传播是如何通过非药物干预和既往发作率的空间变异形成的。我们的研究结果表明，仔细核算的行为和流行病学的背景下出现的变异的关注是必要的，以正确解释他们观察到的相对增长率。
The B.1.1.7 lineage of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused fast-spreading outbreaks globally. Intrinsically, this variant has greater transmissibility than its predecessors, but this capacity has been amplified in some circumstances to tragic effect by a combination of human behavior and local immunity. What are the extrinsic factors that help or hinder the rapid dissemination of variants? Kraemer et al. explored the invasion dynamics of B.1.1.7. in fine detail, from its location of origin in Kent, UK, to its heterogenous spread around the country. A combination of mobile phone and virus data including more than 17,000 genomes shows how distinct phases of dispersal were related to intensity of mobility and the timing of lockdowns. As the local outbreaks grew, importation from the London source area became less important. Had B.1.1.7. emerged at a slightly different time of year, its impact might have been different. —CA Disentangling the factors that contribute to the rapid spread of virus variants is essential for understanding their epidemiological consequences. Understanding the causes and consequences of the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern is crucial to pandemic control yet difficult to achieve because they arise in the context of variable human behavior and immunity. We investigated the spatial invasion dynamics of lineage B.1.1.7 by jointly analyzing UK human mobility, virus genomes, and community-based polymerase chain reaction data. We identified a multistage spatial invasion process in which early B.1.1.7 growth rates were associated with mobility and asymmetric lineage export from a dominant source location, enhancing the effects of B.1.1.7’s increased intrinsic transmissibility. We further explored how B.1.1.7 spread was shaped by nonpharmaceutical interventions and spatial variation in previous attack rates. Our findings show that careful accounting of the behavioral and epidemiological context within which variants of concern emerge is necessary to interpret correctly their observed relative growth rates.
登录
查看更多内容
影响因子：
11.7
作者：
Chowell G;Sattenspiel L;Bansal S;Viboud C
通讯作者：
Viboud C
SARS-COV-2血统的估计可传播和影响B.1.1.7在英国。
DOI：
10.1126/science.abg3055
发表时间：
2021-04-09
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Davies NG;Abbott S;Barnard RC;Jarvis CI;Kucharski AJ;Munday JD;Pearson CAB;Russell TW;Tully DC;Washburne AD;Wenseleers T;Gimma A;Waites W;Wong KLM;van Zandvoort K;Silverman JD;CMMID COVID-19 Working Group;COVID-19 Genomics UK (COG-UK) Consortium;Diaz-Ordaz K;Keogh R;Eggo RM;Funk S;Jit M;Atkins KE;Edmunds WJ
通讯作者：
Edmunds WJ
影响因子：
10.7
作者：
Dellicour S;Durkin K;Hong SL;Vanmechelen B;Martí-Carreras J;Gill MS;Meex C;Bontems S;André E;Gilbert M;Walker C;Maio N;Faria NR;Hadfield J;Hayette MP;Bours V;Wawina-Bokalanga T;Artesi M;Baele G;Maes P
通讯作者：
Maes P
影响因子：
56.9
作者：
Gonzalez-Reiche, Ana S.;Hernandez, Matthew M.;van Bakel, Harm
通讯作者：
van Bakel, Harm
影响因子：
64.8
作者：
通讯作者：
--