Dynamic stabilization of nuclear receptor ligand binding domains by hormone or corepressor binding.
Dynamic stabilization of nuclear receptor ligand binding domains by hormone or corepressor binding.
复制标题
通过激素或辅阻遏物结合实现核受体配体结合域的动态稳定。
DOI：
10.1016/s1097-2765(00)00026-5
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发表时间：
2000
期刊：
影响因子：
16
通讯作者：
Moore,DD
中科院分区：
文献类型：
--
作者：
Pissios,P;Tzameli,I;Kushner,P;Moore,DD
We have developed a novel assembly assay to examine structural changes in the ligand binding domain (LBD) of the thyroid hormone receptor (TR). Fragments including the first helix of the TR LBD interact only weakly with the remainder of the LBD in the absence of hormone, but this interaction is strongly enhanced by the addition of either hormone or the corepressor NCoR. Since neither the ligand nor the corepressor shows direct interaction with this helix, we propose that both exert their effects by stabilizing the overall structure of the LBD. Current models of activation of nuclear hormone receptors focus on a ligand-induced allosteric shift in the position of the C-terminal helix 12 that generates the coactivator binding site. Our results suggest that ligand binding also has more global effects that dynamically alter the structure of the receptor LBD.
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v-ErbA 的沉默子结构域与辅阻遏物协同相互作用：螺旋 5/6 的参与。
影响因子：
--
作者：
K. Busch;B. Martin;A. Baniahmad;J. Martial;R. Renkawitz;M. Muller
通讯作者：
M. Muller
v-erbA 的至少三个子结构域参与其沉默功能。
影响因子：
--
作者：
K. Busch;B. Martin;A. Baniahmad;R. Renkawitz;M. Muller
通讯作者：
M. Muller
影响因子：
64.8
作者：
Nolte, RT;Wisely, GB;Milburn, MV
通讯作者：
Milburn, MV
影响因子：
64.8
作者：
GREEN, S;CHAMBON, P
通讯作者：
CHAMBON, P
甲状腺激素受体的反式激活：与类固醇激素受体的功能相似。
DOI：
10.1073/pnas.86.10.3494
发表时间：
1989
影响因子：
11.1
作者：
C. Thompson;R. Evans
通讯作者：
R. Evans