The pentose phosphate pathway and cancer.
The pentose phosphate pathway and cancer.
复制标题
DOI：
10.1016/j.tibs.2014.06.005
复制
发表时间：
2014-08
影响因子：
13.8
通讯作者：
Hay, Nissim
中科院分区：
文献类型：
--
作者：
Patra, Krushna C.;Hay, Nissim
磷酸戊糖途径（PPP）是糖酵解的分支，是核糖核苷酸合成所必需的，也是NADPH的主要来源。NADPH在脂肪酸合成和活性氧清除过程中是必需和消耗的。因此，PPP在帮助糖酵解癌细胞满足其合成代谢需求和对抗氧化应激方面起着关键作用。最近，几个肿瘤性病变显示已经发展到促进葡萄糖流入戊糖磷酸途径。本文综述了PPP的基本功能，其在癌细胞中的调节，以及其在癌细胞代谢和存活中的重要性。
The pentose phosphate pathway (PPP), which branches from glycolysis at the first committed step of glucose metabolism, is required for the synthesis of ribonucleotides and is a major source of NADPH. NADPH is required for and consumed during fatty acid synthesis and the scavenging of reactive oxygen species. Therefore, the PPP plays a pivotal role in helping glycolytic cancer cells to meet their anabolic demands and combat oxidative stress. Recently, several neoplastic lesions were shown to have evolved to facilitate the flux of glucose into the pentose phosphate pathway. This review summarizes the fundamental functions of the PPP, its regulation in cancer cells, and its importance in cancer cell metabolism and survival.
登录
查看更多内容
影响因子：
64.5
作者：
Clasquin MF;Melamud E;Singer A;Gooding JR;Xu X;Dong A;Cui H;Campagna SR;Savchenko A;Yakunin AF;Rabinowitz JD;Caudy AA
通讯作者：
Caudy AA
DOI：
10.1126/science.1211485
发表时间：
2011-12-02
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Anastasiou D;Poulogiannis G;Asara JM;Boxer MB;Jiang JK;Shen M;Bellinger G;Sasaki AT;Locasale JW;Auld DS;Thomas CJ;Vander Heiden MG;Cantley LC
通讯作者：
Cantley LC
影响因子：
4.1
作者：
EGGLESTON, LV;KREBS, HA
通讯作者：
KREBS, HA
影响因子：
11.4
作者：
Cosentino, Claudia;Grieco, Domenico;Costanzo, Vincenzo
通讯作者：
Costanzo, Vincenzo
影响因子：
16
作者：
Düvel K;Yecies JL;Menon S;Raman P;Lipovsky AI;Souza AL;Triantafellow E;Ma Q;Gorski R;Cleaver S;Vander Heiden MG;MacKeigan JP;Finan PM;Clish CB;Murphy LO;Manning BD
通讯作者：
Manning BD