Development of Neural Response to Novel Sounds in Fragile X Syndrome: Potential Biomarkers.
Development of Neural Response to Novel Sounds in Fragile X Syndrome: Potential Biomarkers.
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DOI：
10.1352/1944-7558-125.6.449
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发表时间：
2020-11-01
期刊：
影响因子：
--
通讯作者：
Berry-Kravis E
中科院分区：
文献类型：
--
作者：
Ethridge L;Thaliath A;Kraff J;Nijhawan K;Berry-Kravis E
脆性X综合征（FXS）的听觉处理异常可能导致语言发展、模式识别和上下文更新方面的困难。FXS组（N=41）和对照组（N=27）在呈现古怪范式时进行了32导联EEG帽的听觉ERP测试。分析将日志年龄作为协变量。33名FXS参与者和27名对照（年龄4-51岁，13名女性（FXS））的数据足以进行分析；4-54岁，雌性11例（对照）。与对照组相比，患有FXS的女性表现出更大的N1和P2波幅（p< 0.05），对古怪刺激的ERP波幅调节异常，包括P1和P2波幅缺乏正常的增加（p=0.037）和P2潜伏期的正常减慢（p<0.001）。FXS的参与者在任务过程中显示出P2潜伏期的边际加速，表明对奇怪刺激的增强而不是习惯化，F(1,55)=3.7, p=0.05。与对照组相比，FXS的参与者对标准表现出更高的N1习惯效应，F(1,55)=4.5, p=0.03。FXS F(1,55)=10.1, p=0.002时，参与者的Gamma功率显著更高。FXS组和对照组在错配负性上没有差异。对照组和FXS参与者的P1振幅随年龄的增长而显著降低，而N1振幅、P2潜伏期和伽马功率随年龄的增长而增加。然而，对照组而非FXS参与者的P2振幅随着年龄的增长而下降。对14名参与者进行了为期一个月的重测分析，结果表明大多数测量结果具有较强的重测信度（ICC范围为0.65至0.96,p <0.05），失配阴性（ICC =0.57, p=0.06）和P2振幅和延迟到古怪（p 's >0.05）的边缘信度。FXS个体表现出先前表现出的反应幅度和高频神经活动增加。此外，尽管在大多数测量中，FXS个体的总体发育轨迹是正常的，但在新刺激的复杂加工中，FXS个体表现出与年龄无关但与性别相关的下降。许多标记物即使在儿童中也显示出很强的重测可靠性，因此是FXS临床试验的潜在生物标记物。
Auditory processing abnormalities in fragile X syndrome (FXS) may contribute to difficulties with language development, pattern identification, and contextual updating. Participants with FXS (N=41) and controls (N=27) underwent auditory ERP with a 32 lead EEG cap during presentation of an oddball paradigm. Analyses included log age as a covariate. Data was adequate for analysis for 33 participants with FXS and 27 controls (age 4-51y, 13 females (FXS); 4-54y,11 females (control)). Participants with FXS showed larger N1 and P2 amplitudes (p’s<0.05), abnormal modulation of ERP amplitudes in response to oddball stimuli including lack of normal increases in P1 (p=0.037) and P2 (p=0.008) amplitudes and normal slowing of P2 latency (p<0.001) relative to controls: Females with FXS were more similar to controls. Participants with FXS showed a marginal speeding of the P2 latency during the task, suggesting potentiation to oddball stimuli rather than habituation, F(1,55)=3.7, p=0.05. Participants with FXS showed a heightened N1 habituation effect to standards compared to controls, F(1,55)=4.5, p=0.03. Gamma power was significantly higher for participants with FXS F(1,55)=10.1, p=0.002. Participants with FXS and controls did not differ on mismatch negativity. Both controls and participants with FXS showed significant decreases in P1 amplitude, and increases in N1 amplitude, P2 latency, and gamma power with age. However, controls but not participants with FXS show a decrease in P2 amplitude with age. Retest analyses performed in 14 participants with one month retest suggest strong test-retest reliability (ICC range 0.65 to 0.96, p’s <0.05) for most measures, and borderline reliability for mismatch negativity (ICC =0.57, p=0.06), and P2 amplitude and latency to oddball (p’s>0.05). Individuals with FXS show previously demonstrated increased in response amplitude and high frequency neural activity. Additionally, despite an overall normal developmental trajectory for most measures, individuals with FXS show age-independent but gender-dependent decreases in complex processing of novel stimuli. Many markers show strong retest reliability even in children and thus are potential biomarkers for clinical trials in FXS.
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影响因子：
4.9
作者：
Lee M;Martin GE;Berry-Kravis E;Losh M
通讯作者：
Losh M
DOI：
10.1098/rstb.2005.1622
发表时间：
2005-04-29
影响因子：
6.3
作者：
Friston, KJ
通讯作者：
Friston, KJ
DOI：
10.1016/j.clinph.2008.11.029
发表时间：
2009-03
期刊：
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
影响因子：
--
作者：
Garrido MI;Kilner JM;Stephan KE;Friston KJ
通讯作者：
Friston KJ
影响因子：
2.5
作者：
Ludlow, Amanda;Mohr, Bettina;Gutierrez, Roberto
通讯作者：
Gutierrez, Roberto
影响因子：
2.5
作者：
Gibson, Jay R.;Bartley, Aundrea F.;Huber, Kimberly M.
通讯作者：
Huber, Kimberly M.