T cells modulate glycans on CD43 and CD45 during development and activation, signal regulation, and survival.
T cells modulate glycans on CD43 and CD45 during development and activation, signal regulation, and survival.
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DOI：
10.1111/j.1749-6632.2011.06304.x
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发表时间：
2012-04
影响因子：
5.2
通讯作者：
Baum LG
中科院分区：
文献类型：
--
作者：
Clark MC;Baum LG
糖基化影响许多必需的T细胞过程，并且在T细胞的整个寿命中受到内在控制。CD 43和CD 45是T细胞表面上最丰富的两种糖蛋白，并被O-和N-聚糖修饰。在胸腺细胞发育和T细胞活化过程中，调节整体T细胞糖基化和CD 43和CD 45的特异性糖基化; T细胞通过调节糖基转移酶和糖苷酶的表达来控制修饰CD 43和CD 45的聚糖的类型和丰度。此外，T细胞通过表达具有不同聚糖附着位点的CD 45的选择性剪接同种型来调节CD 45的糖基化。T细胞上CD 43和CD 45的糖表型影响T细胞如何与细胞外环境相互作用，包括T细胞如何与内源性凝集素相互作用。本文综述了在整个T细胞发育和活化过程中发生的CD 43和CD 45糖基化的变化，以及糖基化在调节T细胞过程中的作用，如迁移，T细胞受体信号传导和凋亡。
Glycosylation affects many essential T cell processes and is intrinsically controlled throughout the lifetime of a T cell. CD43 and CD45 are the two most abundant glycoproteins on the T cell surface and are decorated with O- and N-glycans. Global T cell glycosylation and specific glycosylation of CD43 and CD45 are modulated during thymocyte development and T cell activation; T cells control the type and abundance of glycans decorating CD43 and CD45 by regulating expression of glycosyltransferases and glycosidases. Additionally, T cells regulate glycosylation of CD45 by expressing alternatively spliced isoforms of CD45 that have different glycan attachment sites. The glycophenotype of CD43 and CD45 on T cells influences how T cells interact with the extracellular environment, including how T cells interact with endogenous lectins. This review focuses on changes in glycosylation of CD43 and CD45 occurring throughout T cell development and activation and the role that glycosylation plays in regulating T cell processes, such as migration, T cell receptor signaling, and apoptosis.
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