Epigenetics and cardiovascular disease.
Epigenetics and cardiovascular disease.
复制标题
DOI：
10.1038/nrcardio.2010.104
复制
发表时间：
2010-09
影响因子：
49.6
通讯作者：
Smith, Caren E.
中科院分区：
文献类型：
--
作者：
Ordovas, Jose M.;Smith, Caren E.
尽管心血管疾病 (CVD) 的预防和管理取得了进展，但这类多因素疾病仍然是全世界死亡的主要原因。 CVD 与多种遗传和可改变的危险因素有关；然而，已知的环境和遗传影响只能解释CVD风险变异性的一小部分，这是其预防和治疗的主要障碍。因此，需要更全面地了解导致 CVD 的因素，以开发更有效且更具成本效益的治疗方法。 “组学”技术的应用有望使这些进步成为现实。表观基因组学已成为最有前途的领域之一，它将弥补我们目前对 CVD 发展中先天与后天相互作用的认识上的一些空白。表观遗传机制包括 DNA 甲基化、组蛋白修饰和 microRNA 改变，这些机制共同使细胞能够对环境变化做出快速反应。许多CVD危险因素，如营养、吸烟、污染、压力和昼夜节律，都与表观遗传标记的改变有关。对这些机制的进一步检查可能会导致 CVD 的早期预防和新疗法。
Despite advances in the prevention and management of cardiovascular disease (CVD), this group of multifactorial disorders remains a leading cause of mortality worldwide. CVD is associated with multiple genetic and modifiable risk factors; however, known environmental and genetic influences can only explain a small part of the variability in CVD risk, which is a major obstacle for its prevention and treatment. A more thorough understanding of the factors that contribute to CVD is, therefore, needed to develop more efficacious and cost-effective therapy. Application of the ‘omics’ technologies will hopefully make these advances a reality. Epigenomics has emerged as one of the most promising areas that will address some of the gaps in our current knowledge of the interaction between nature and nurture in the development of CVD. Epigenetic mechanisms include DNA methylation, histone modification, and microRNA alterations, which collectively enable the cell to respond quickly to environmental changes. A number of CVD risk factors, such as nutrition, smoking, pollution, stress, and the circadian rhythm, have been associated with modification of epigenetic marks. Further examination of these mechanisms may lead to earlier prevention and novel therapy for CVD.
登录
查看更多内容
影响因子：
4.8
作者：
Balasubramanyam, K;Varier, RA;Kundu, TK
通讯作者：
Kundu, TK
影响因子：
5.3
作者：
Buysschaert I;Schmidt T;Roncal C;Carmeliet P;Lambrechts D
通讯作者：
Lambrechts D
影响因子：
2.9
作者：
Chen, ZX;Riggs, AD
通讯作者：
Riggs, AD
DOI：
10.1164/rccm.200807-1097oc
发表时间：
2009-04-01
影响因子：
24.7
作者：
Baccarelli, Andrea;Wright, Robert O.;Schwartz, Joel
通讯作者：
Schwartz, Joel
影响因子：
4.2
作者：
Fang, Mingzhu;Chen, Dapeng;Yang, Chung S.
通讯作者：
Yang, Chung S.