Combination of the Framingham risk score and carotid intima-media thickness improves the prediction of cardiovascular events in patients with type 2 diabetes.
Combination of the Framingham risk score and carotid intima-media thickness improves the prediction of cardiovascular events in patients with type 2 diabetes.
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DOI：
10.2337/dc11-1333
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发表时间：
2012-01
期刊：
影响因子：
16.2
通讯作者：
Watada H
中科院分区：
文献类型：
--
作者：
Yoshida M;Mita T;Yamamoto R;Shimizu T;Ikeda F;Ohmura C;Kanazawa A;Hirose T;Kawamori R;Watada H
本研究的目的是探讨颈动脉内膜-中膜厚度（IMT）和臂踝脉搏波速度（baPWV）是否在预测心血管疾病（CVD）阴性史的2型糖尿病患者的Framingham风险评分（FRS）中增加了价值。回顾性招募2型糖尿病患者（n = 783）并随访CVD。在5.4年的随访期间，记录了85例CVD发病率（10.9%）。在对传统动脉危险因素进行校正后，采用Cox比例风险模型进行多因素分析，发现IMT是CVD的重要决定因素，而baPWV不是。此外，FRS与IMT联合，而不与baPWV联合，提高了CVD的预测。颈动脉IMT是无症状2型糖尿病患者CVD的重要预测指标，FRS和IMT联合应用可提高对这些患者CVD的预测。
The aim of this study was to investigate whether carotid intima-media thickness (IMT) and brachial-ankle pulse wave velocity (baPWV) add value to the Framingham risk score (FRS) in predicting the development of cardiovascular diseases (CVDs) in type 2 diabetic patients with a negative history of CVD. Type 2 diabetic patients (n = 783) were retrospectively recruited and followed for CVD. During a 5.4-year follow-up period, 85 incidences of CVD were recorded (10.9%). After adjustment for conventional arterial risk factors, multivariate analysis with the Cox proportional hazards model identified IMT, but not baPWV, as a significant determinant of CVD. In addition, the combination of FRS with IMT, but not with baPWV, improved the prediction of CVD. Carotid IMT is a significant predictor of CVD in asymptomatic type 2 diabetic patients, and the combination of FRS and IMT improves the prediction of CVD in these patients.
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DOI：
10.1161/atvbaha.107.152835
发表时间：
2007-11-01
影响因子：
8.7
作者：
Mita, Tomoya;Watada, Hirotaka;Kawamori, Ryuzo
通讯作者：
Kawamori, Ryuzo
影响因子：
37.8
作者：
Wilson, PWF;D'Agostino, RB;Kannel, WB
通讯作者：
Kannel, WB
影响因子：
16.2
作者：
Coleman, Ruth L.;Stevens, Richard J.;Holman, Rury R.
通讯作者：
Holman, Rury R.
影响因子：
5.3
作者：
Mita, Tomoya;Watada, Hirotaka;Kawamori, Ryuzo
通讯作者：
Kawamori, Ryuzo
影响因子：
--
作者：
Ramachandran, S;French, JM;Neary, RH
通讯作者：
Neary, RH