Dynamic compression of human and ovine meniscal tissue compared with a potential thermoplastic elastomer hydrogel replacement.
Dynamic compression of human and ovine meniscal tissue compared with a potential thermoplastic elastomer hydrogel replacement.
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DOI：
10.1002/jbm.a.36129
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发表时间：
2017-10
期刊：
影响因子：
--
通讯作者：
Haut Donahue TL
中科院分区：
文献类型：
--
作者：
Fischenich KM;Boncella K;Lewis JT;Bailey TS;Haut Donahue TL
了解人类直肠组织如何响应模拟日常生活的负荷机制，以及它如何与较大的动物模型进行比较，对于开发功能准确的合成替代物至关重要。将7个人和8个绵羊尸体直肠标本局部切成直径为5 mm、沿着厚为3 mm的圆柱体，圆柱体上有10种聚苯乙烯-b-聚环氧乙烷嵌段共聚物基热塑性弹性体（TPE）水凝胶。将样品在1 Hz下压缩至12%应变，持续5000次循环，卸载24小时，然后重新测试。在测试一和测试二之间没有发现每组内的差异。人和绵羊组织显示无区域依赖性（p<0.05）。人体样品比绵羊组织或TPE水凝胶松弛更快，第50次循环的模量值与第5000次循环的模量值无显著差异。发现绵羊组织的松弛曲线与人类组织相似，但具有显著更高的模量值（瞬时为3.44MPa，5000次循环后为0.61MPa，而人类组织为1.97MPa和0.11MPa）和显著不同的幂律拟合系数。TPE水凝胶具有0.58MPa的初始模量，并且在5000 ° C下经历小于20%的总松弛。观察到人和绵羊椎间盘之间的压缩模量大小存在显著差异，但松弛曲线相似。尽管与天然组织存在统计学差异，但TPE水凝胶材料的模量值与人类和绵羊盲肠的模量值相似，因此其是一种值得进一步研究的材料，可用作合成替代品。
Understanding how human meniscal tissue responds to loading regimes mimetic of daily life as well as how it compares to larger animal models is critical in the development of a functionally accurate synthetic surrogate. Seven human and 8 ovine cadaveric meniscal specimens were regionally sectioned into cylinders 5mm in diameter and 3 mm thick along with 10 polystyrene-b-polyethylene oxide block copolymer-based thermoplastic elastomer (TPE) hydrogels. Samples were compressed to 12% strain at 1 Hz for 5000 cycles, unloaded for 24 hours, and then retested. No differences were found within each group between test one and test two. Human and ovine tissue exhibited no regional dependency (p<0.05). Human samples relaxed quicker than ovine tissue or the TPE hydrogel with modulus values at cycle 50 not significantly different from cycle 5000. Ovine menisci were found to be similar to human menisci in relaxation profile but had significantly higher modulus values (3.44MPa instantaneous and 0.61MPa after 5000 cycles compared to 1.97MPa and 0.11MPa found for human tissue) and significantly different power law fit coefficients. The TPE hydrogel had an initial modulus of 0.58MPa and experienced less than a 20% total relaxation over the 5000. Significant differences in the magnitude of compressive modulus between human and ovine menisci were observed, however the relaxation profiles were similar. Although statistically different than the native tissues, modulus values of the TPE hydrogel material were similar to those of the human and ovine menisci, making it a material worth further investigation for use as a synthetic replacement.
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DOI：
10.1007/s00167-014-3009-2
发表时间：
2015-08
期刊：
Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA
影响因子：
--
作者：
Gruchenberg K;Ignatius A;Friemert B;von Lübken F;Skaer N;Gellynck K;Kessler O;Dürselen L
通讯作者：
Dürselen L
DOI：
10.1002/jbm.820290706
发表时间：
1995-07-01
期刊：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH
影响因子：
--
作者：
JOSHI, MD;SUH, JK;WOO, SLY
通讯作者：
WOO, SLY
DOI：
10.1115/1.3138409
发表时间：
1983-01-01
影响因子：
1.7
作者：
AHMED, AM;BURKE, DL
通讯作者：
BURKE, DL
DOI：
10.1243/0954411001535651
发表时间：
2000-01-01
影响因子：
1.8
作者：
Leslie, BW;Gardner, DL;Moran, RS
通讯作者：
Moran, RS
影响因子：
4.8
作者：
Kelly, Bryan T.;Potter, Hollis G.;Rodeo, Scott A.
通讯作者：
Rodeo, Scott A.