Evaluation of surrogate measures of pulmonary function derived from electrical impedance tomography data in children with cystic fibrosis.
Evaluation of surrogate measures of pulmonary function derived from electrical impedance tomography data in children with cystic fibrosis.
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DOI：
10.1088/1361-6579/aab8c4
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发表时间：
2018-04-26
影响因子：
3.2
通讯作者：
Hoppe J
中科院分区：
文献类型：
--
作者：
Muller PA;Mueller JL;Mellenthin M;Murthy R;Capps M;Wagner BD;Alsaker M;Deterding R;Sagel SD;Hoppe J
肺功能监测肺功能在儿科囊性纤维化（CF）患者的临床护理中起着至关重要的作用，但许多年幼的儿童无法进行肺功能测定，即使在肺部疾病的存在下，输出也通常正常。研究了来自电阻抗断层扫描（EIT）图像的测量结果，以确定其作为CF患者肺功能测定的潜在替代品的实用性，并评估了一部分患者对静脉内抗生素治疗急性肺加重（PEX）的反应。在潮式呼吸期间收集了35例2 - 20岁受试者（21例CF，14例健康对照，8例CF患者治疗前和治疗后的急性PEX）的EIT数据，同时还对8岁以上受试者进行了肺功能测定。从动态EIT图像中计算EIT衍生的FEV 1、FVC和FEV 1/FVC的整体和区域测量值。整体EIT导出的FEV 1/FVC与肺量测定法FEV 1/FVC值显示出良好的相关性（r=0.54，p=0.01），并且能够区分各组（p=0.01）。通过关键时间点之间EIT差异图像的空间变异系数（CV）评估肺异质性，EIT衍生的FEV 1和FVC的CV与潮气呼吸的CV显著相关（分别为r=0.47，p=0.01和r=0.50，p=0.01）。总体EIT导出的FEV 1/FVC比肺量测定法FEV 1更能区分两组（F值分别为776.5和146.3，p<0.01）。EIT衍生的FEV 1、FVC和潮气呼吸的CV也是如此（F值分别为215.93、193.89、204.57，p<0.01）。
Lung function monitoring by spirometry plays a critical role in the clinical care of pediatric cystic fibrosis (CF) patients, but many young children are unable to perform spirometry, and the outputs are often normal even in the presence of lung disease. Measures derived from electrical impedance tomography (EIT) images were studied for their utility as potential surrogates for spirometry in CF patients and to assess response to intravenous antibiotic treatment for acute pulmonary exacerbations (PEx) in a subset of patients. EIT data were collected on 35 subjects (21 with CF, 14 healthy controls, 8 CF patients pre- and post-treatment for an acute PEx) ages 2 to 20 years during tidal breathing and also concurrently with spirometry on subjects over age 8. EIT-derived measures of FEV1, FVC, and FEV1/FVC were computed globally and regionally from dynamic EIT images. Global EIT-derived FEV1/FVC showed good correlation with spirometry FEV1/FVC values (r=0.54, p=0.01), and were able to distinguish between the groups (p=0.01). Lung heterogeneity was assessed through the spatial coefficient of variation (CV) of EIT difference images between key time points, and the CVs for EIT-derived FEV1 and FVC showed significant correlation with the CV for tidal breathing (r=0.47, p=0.01 and r=0.50, p=0.01, respectively). Global EIT-derived FEV1/FVC was better able to distinguish between groups than spirometry FEV1 (F-values 776.5 and 146.3, respectively, p<0.01.) The same held true for the CVs for EIT-derived FEV1, FVC, and Tidal Breathing (F-values 215.93, 193.89, 204.57, respectively, p<0.01.)
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DOI：
10.1183/09031936.00080312
发表时间：
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期刊：
The European respiratory journal
影响因子：
--
作者：
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发表时间：
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期刊：
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影响因子：
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