In vitro degradation and fermentation of three dietary fiber sources by human colonic bacteria.
In vitro degradation and fermentation of three dietary fiber sources by human colonic bacteria.
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DOI：
10.1021/jf3054017
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发表时间：
2013-05-15
影响因子：
6.1
通讯作者：
Savik K
中科院分区：
文献类型：
--
作者：
Bliss DZ;Weimer PJ;Jung HJ;Savik K
虽然膳食纤维补充剂的临床益处似乎部分取决于纤维降解和结肠细菌发酵的程度，但关于补充纤维类型对细菌代谢的影响知之甚少。在使用来自三名正常受试者的非适应性人类细菌群体的实验中，阿拉伯树胶（GA）的体外发酵程度大于车前子（PSY），车前子（PSY）大于羧甲基纤维素（CMC）。在一项单独的实验中，在随机分配和消耗三种纤维（GA，PSY或CMC）补充剂或安慰剂20- 21天之前和之后，用52名大便失禁受试者的粪便进行体外孵育，表明先前消耗特定纤维源不会增加粪便细菌的降解。结果表明，在特定纤维基质上富集的结肠微生物群落可以快速适应新纤维基质的呈现。这些发现的临床意义是，人类摄入纤维源预计不会导致细菌适应，这将需要持续更大且最终无法忍受的纤维量来实现治疗益处。
Although clinical benefits of dietary fiber supplementation seem to depend partially on the extent of fiber degradation and fermentation by colonic bacteria, little is known about the effect of supplemental fiber type on bacterial metabolism. In an experiment using a non-adapted human bacterial population from three normal subjects, extent of in vitro fermentation was greater for gum arabic (GA) than for psyllium (PSY), which was greater than that for carboxymethylcellulose (CMC). In a separate experiment, in vitro incubation with feces from 52 subjects with fecal incontinence, before and after random assignment to and consumption of one of three fiber (GA, PSY, or CMC) supplements or a placebo for 20-21d, indicated that prior consumption of a specific fiber source did not increase its degradation by fecal bacteria. Results suggest that the colonic microbial community enriched on a particular fiber substrate can rapidly adapt to the presentation of a new fiber substrate. Clinical implications of the findings are that intake of a fiber source by humans is not expected to result in bacterial adaptation that would require continually larger and eventually intolerable amounts of fiber to achieve therapeutic benefits.
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影响因子：
1.6
作者：
Macfarlane, George T.;Macfarlane, Sandra
通讯作者：
Macfarlane, Sandra
影响因子：
--
作者：
Gueorguieva, R;Krystal, JH
通讯作者：
Krystal, JH
DOI：
10.1348/000711001159357
发表时间：
2001-05-01
影响因子：
2.6
作者：
Keselman, HJ;Algina, J;Kowalchuk, RK
通讯作者：
Kowalchuk, RK
影响因子：
2.5
作者：
Bliss, Donna Z.;Savik, Kay;Lowry, Ann
通讯作者：
Lowry, Ann
影响因子：
1.9
作者：
BOURQUIN, LD;TITGEMEYER, EC;GARLEB, KA
通讯作者：
GARLEB, KA