Induction of intestinal Th17 cells by segmented filamentous bacteria.
Induction of intestinal Th17 cells by segmented filamentous bacteria.
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DOI：
10.1016/j.cell.2009.09.033
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发表时间：
2009-10-30
期刊：
影响因子：
64.5
通讯作者：
Littman DR
中科院分区：
文献类型：
--
作者：
Ivanov II;Atarashi K;Manel N;Brodie EL;Shima T;Karaoz U;Wei D;Goldfarb KC;Santee CA;Lynch SV;Tanoue T;Imaoka A;Itoh K;Takeda K;Umesaki Y;Honda K;Littman DR
哺乳动物的胃肠道中居住着数百种不同种类的肠道微生物，它们与宿主存在互惠关系。肠道微生物群如何影响宿主免疫系统还知之甚少。我们在这里表明，一个单一的肠道微生物，分节丝状细菌（SFB）的小鼠小肠的殖民化，足以诱导CD 4 + T辅助细胞的出现，产生IL-17和IL-22（Th 17细胞）在固有层。SFB紧密粘附于具有Th 17细胞的小鼠的回肠末端中的上皮细胞的表面，但在具有很少Th 17细胞的小鼠中不存在。SFB的定植与炎症和抗微生物防御相关基因的表达增加相关，并导致对肠道病原体啮齿类柠檬酸杆菌的抗性增强。因此，操纵这一神经系统调节的途径可能为增强粘膜免疫和治疗自身免疫性疾病提供新的机会。
The gastrointestinal tract of mammals is inhabited by hundreds of distinct species of commensal microorganisms that exist in a mutualistic relationship with the host. How commensal microbiota influence the host immune system is poorly understood. We show here that colonization of the small intestine of mice with a single commensal microbe, segmented filamentous bacterium (SFB), is sufficient to induce the appearance of CD4+ T helper cells that produce IL-17 and IL-22 (Th17 cells) in the lamina propria. SFB adhere tightly to the surface of epithelial cells in the terminal ileum of mice with Th17 cells but are absent from mice that have few Th17 cells. Colonization with SFB was correlated with increased expression of genes associated with inflammation and anti-microbial defenses, and resulted in enhanced resistance to the intestinal pathogen Citrobacter rodentium. Thus, manipulation of this commensalregulated pathway may provide new opportunities for enhancing mucosal immunity and treating autoimmune disease.
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