Change in area of geographic atrophy in the Age-Related Eye Disease Study: AREDS report number 26.
Change in area of geographic atrophy in the Age-Related Eye Disease Study: AREDS report number 26.
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与年龄有关的眼病研究中，地理萎缩面积的变化：AREDS报告编号26。
DOI：
10.1001/archophthalmol.2009.198
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发表时间：
2009-09
期刊：
影响因子：
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通讯作者：
Age-Related Eye Disease Study Research Group
中科院分区：
文献类型：
--
作者：
Lindblad AS;Lloyd PC;Clemons TE;Gensler GR;Ferris FL 3rd;Klein ML;Armstrong JR;Age-Related Eye Disease Study Research Group
通过数字化眼底照片测量，描述AREDS中与年龄相关性黄斑变性相关的地图状萎缩（GA）的进展。对基线时GA面积至少为0.5个椎间盘面积的4757名AREDS参与者中的181名或随访期间发生双侧GA的参与者的眼底照片进行扫描、数字化和纵向评价。使用面积测量法确定地理萎缩面积。从非中心性GA到中心性GA的进展率和发生中心性GA后的视力丧失率包括整个AREDS队列。中位初始病变尺寸为4.3 mm 2。第1年时GA指面积相对于基线的平均变化为2.03 mm 2（平均值的标准误为0.24 mm 2），第2年为3.78 mm 2（0.24 mm 2），第3年为5.93 mm 2（0.34 mm 2），总体每年为1.78 mm 2（0.086 mm 2）。任何GA诊断后发展为中央GA的中位时间为2.5年（95%置信区间，2.0-3.0）。首次记录中央GA时，平均视力下降3.7个字母，第5年时下降22个字母。GA区域的生长可以使用标准眼底照片可靠地测量，所述标准眼底照片被数字化并随后在阅读中心分级。GA的发展与随后GA的进一步生长、中央GA的发展和中央视觉的丧失相关。
To characterize progression of geographic atrophy (GA) associated with age-related macular degeneration in AREDS as measured by digitized fundus photographs. Fundus photographs from 181 of 4757 AREDS participants with a GA area of at least 0.5 disc areas at baseline or from participants who developed bilateral GA during follow-up were scanned, digitized, and evaluated longitudinally. Geographic atrophy area was determined using planimetry. Rates of progression from noncentral to central GA and of vision loss following development of central GA included the entire AREDS cohort. Median initial lesion size was 4.3 mm2. Average change in digital area of GA from baseline was 2.03 mm2 (standard error of the mean, 0.24 mm2) at 1 year, 3.78 mm2 (0.24 mm2) at 2 years, 5.93 mm2 (0.34 mm2) at 3 years, and 1.78 mm2 (0.086 mm2) per year overall. Median time to developing central GA after any GA diagnosis was 2.5 years (95% confidence interval, 2.0-3.0). Average visual acuity decreased by 3.7 letters at first documentation of central GA, and by 22 letters at year 5. Growth of GA area can be reliably measured using standard fundus photographs that are digitized and subsequently graded at a reading center. Development of GA is associated with subsequent further growth of GA, development of central GA, and loss in central vision.
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影响因子：
--
作者：
Kassoff, A;Kassoff, J;Chew, EY
通讯作者：
Chew, EY
影响因子：
1.8
作者：
Dreyhaupt, J;Mansmann, U;Holz, FG
通讯作者：
Holz, FG
影响因子：
4.4
作者：
Schmitz-Valckenberg, Steffen;Bindewald-Wittich, Almut;Holz, Frank G.
通讯作者：
Holz, Frank G.
DOI：
10.1097/00006982-200607000-00013
发表时间：
2006-07-01
影响因子：
3.3
作者：
Sunness, Janet S.;Ziegler, Matthias D.;Applegate, Carol A.
通讯作者：
Applegate, Carol A.
影响因子：
--
作者：
SUNNESS, JS;JOHNSON, MA;MARCUS, S
通讯作者：
MARCUS, S