ApoE4 Is Associated with Lower Body Mass, Particularly Fat Mass, in Older Women with Cognitive Impairment.
ApoE4 Is Associated with Lower Body Mass, Particularly Fat Mass, in Older Women with Cognitive Impairment.
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在有认知障碍的老年女性中，载脂蛋白E4与下体质量，特别是脂肪质量有关。
DOI：
10.3390/nu14030539
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发表时间：
2022-01-26
期刊：
影响因子：
5.9
通讯作者：
Sakurai T
中科院分区：
文献类型：
--
作者：
Ando T;Uchida K;Sugimoto T;Kimura A;Saji N;Niida S;Sakurai T
较低的体重与阿尔茨海默病（AD）的进展和AD患者的死亡风险相关;然而，认知受损老年人体重下降的遗传决定因素的证据有限。因此，我们研究了APOE-ε4对轻度认知障碍（MCI）和早中期AD老年人身体组成的遗传效应。共1631例MCI和早中期AD门诊患者（年龄65-89岁），评估了身体成分与APOE-ε4状态之间的关系。在调整了协变量后，包括用简易精神状态检查评估的认知功能，APOE-ε4的存在与体重降低相关。（每次出现β = −1.116 ± 0.468 kg，p = 0.017），脂肪量（每次出现β =-1.196 ± 0.401 kg，p = 0.003），女性的体脂百分比（每次出现β =-1.700 ± 0.539%，p = 0.002），但男性没有。此外，APOE-ε4对女性身体组成测量的影响在MCI中比在AD患者中更显著。APOE-ε4等位基因的存在与较低的脂肪量相关，特别是在MCI女性中，与认知能力下降无关。
A lower body mass is associated with the progression of Alzheimer’s disease (AD) and the risk of mortality in patients with AD; however, evidence of genetic determinants of decreased body mass in cognitively impaired older adults is limited. We therefore investigated the genetic effect of APOE-ε4 on body composition in older adults with mild cognitive impairment (MCI) and early-to-moderate-stage AD. A total of 1631 outpatients (aged 65–89 years) with MCI and early-to-moderate-stage AD were evaluated for the association between body composition and APOE-ε4 status. After adjusting for covariates, including cognitive function evaluated with the Mini-Mental State Examination, the presence of the APOE-ε4 was associated with lower weight (β = −1.116 ± 0.468 kg per presence, p = 0.017), fat mass (β = −1.196 ± 0.401 kg per presence, p = 0.003), and percentage of body fat (β = −1.700 ± 0.539% per presence, p = 0.002) in women but not in men. Additionally, the impact of APOE-ε4 on measures of body composition in women was more remarkable in MCI than in AD patients. The presence of the APOE-ε4 allele was associated with lower fat mass, particularly in women with MCI, independent of cognitive decline.
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DOI：
10.1016/j.jalz.2011.03.005
发表时间：
2011-05
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
McKhann GM;Knopman DS;Chertkow H;Hyman BT;Jack CR Jr;Kawas CH;Klunk WE;Koroshetz WJ;Manly JJ;Mayeux R;Mohs RC;Morris JC;Rossor MN;Scheltens P;Carrillo MC;Thies B;Weintraub S;Phelps CH
通讯作者：
Phelps CH
DOI：
10.1007/s12603-017-0906-3
发表时间：
2017
期刊：
The journal of nutrition, health & aging
影响因子：
--
作者：
Bell SP;Liu D;Samuels LR;Shah AS;Gifford KA;Hohman TJ;Jefferson AL
通讯作者：
Jefferson AL
影响因子：
--
作者：
Burns, Jeffrey M.;Johnson, David K.;Watts, Amber;Swerdlow, Russell H.;Brooks, William M.
通讯作者：
Brooks, William M.
DOI：
10.1016/j.jalz.2011.03.008
发表时间：
2011-05
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Albert MS;DeKosky ST;Dickson D;Dubois B;Feldman HH;Fox NC;Gamst A;Holtzman DM;Jagust WJ;Petersen RC;Snyder PJ;Carrillo MC;Thies B;Phelps CH
通讯作者：
Phelps CH
影响因子：
4.8
作者：
FOLSTEIN, MF;FOLSTEIN, SE;MCHUGH, PR
通讯作者：
MCHUGH, PR