Medication adherence in healthy elders: small cognitive changes make a big difference.
Medication adherence in healthy elders: small cognitive changes make a big difference.
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DOI：
10.1177/0898264309332836
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发表时间：
2009-06
影响因子：
2.8
通讯作者：
Kaye JA
中科院分区：
文献类型：
--
作者：
Hayes TL;Larimer N;Adami A;Kaye JA
这是一项关于独立生活的健康老年人遵循药物治疗方案的能力的横断面研究。参与者根据他们在ADAS-Cog上的得分分为高认知功能（HCF）或低认知功能（LCF）组。38名年龄在65岁或65岁以上的参与者在社区独立生活，每天服用两次维生素C，持续五周。使用电子7天药盒测量依从性。LCF组的总依从性显著差于HCF组（LCF：63.9 ± 11.2%，HCF：86.8 ± 4.3%，t36=2.57，p=0.007），LCF组与HCF组相比，不依从性的相对风险为4.1。这项研究提供了强有力的证据，即使是非常轻微的认知障碍，在社区独立生活的健康老年人有一个有害的和显着的影响，坚持药物治疗方案。这项研究对在这一人群中进行临床药物试验具有重要意义。
This was a cross-sectional study of the ability of independently living healthy elders to follow a medication regimen. Participants were divided into a group with High Cognitive Function (HCF) or Low Cognitive Function (LCF) based on their scores on the ADAS-Cog. Thirty-eight participants aged 65 or older and living independently in the community followed a twice-daily vitamin C regimen for five weeks. Adherence was measured using an electronic 7-day pill box. The LCF group had significantly poorer total adherence than the HCF group (LCF: 63.9 ± 11.2%, HCF: 86.8 ± 4.3%, t36=2.57, p=0.007), and there was a 4.1 relative risk of non-adherence in the LCF group as compared to the HCF group. This study provides strong evidence that even very mild cognitive impairment in healthy elderly living independently in the community has a detrimental and significant impact on adherence to a medication regimen. This study has important implications for the conduct of clinical drug trials in this population.
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影响因子：
2.5
作者：
Cargin, JW;Maruff, P;Masters, C
通讯作者：
Masters, C
影响因子：
16.2
作者：
Paes, AHP;Bakker, A;SoeAgnie, CJ
通讯作者：
SoeAgnie, CJ
DOI：
10.1046/j.1440-1614.2002.00972.x
发表时间：
2002-02-01
影响因子：
4.6
作者：
Collie, A;Maruff, P
通讯作者：
Maruff, P
遵守糖尿病患者和缺血性心脏病患者的心脏保护药物和死亡率。
影响因子：
2.1
作者：
Ho PM;Magid DJ;Masoudi FA;McClure DL;Rumsfeld JS
通讯作者：
Rumsfeld JS
影响因子：
120.7
作者：
CRAMER, JA;MATTSON, RH;OUELLETTE, VL
通讯作者：
OUELLETTE, VL