Ferroptosis assassinates tumor.
Ferroptosis assassinates tumor.
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DOI：
10.1186/s12951-022-01663-8
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发表时间：
2022-11-03
影响因子：
10.2
通讯作者：
Wang, Jinke
中科院分区：
文献类型：
--
作者：
Luo, Tao;Wang, Yile;Wang, Jinke
2020年，全球近2000万人罹患癌症，近1000万人死于癌症，表明癌症仍然是人类健康和生命的巨大威胁。新的治疗方法仍然是迫切需要的。我们在这里开发了一种新的癌症治疗方法，名为铁凋亡ASsassinates肿瘤（FAST），通过将氧化铁纳米颗粒与七个关键的铁凋亡抗性基因（FPN，LCN 2，FTH 1，FSP 1，GPX 4，SLC 7A 11，NRF 2）的癌症选择性敲低相结合。我们发现FAST在多种癌细胞中具有显著的抗肿瘤活性，但对正常细胞的影响很小。特别是，FAST从超过50%的癌症小鼠中根除了三种不同类型的肿瘤（白血病，结肠癌和肺转移性黑色素瘤），使小鼠存活长达250天而没有肿瘤复发。FAST还显著抑制和预防了自发性乳腺癌的生长，并提高了小鼠的存活率。FAST显示出高泛抗肿瘤功效、高癌症特异性和体内安全性。FAST定义了一种新形式的先进纳米材料--先进组合纳米材料，通过将一种化学纳米材料（氧化铁纳米颗粒）和一种生化纳米材料（腺相关病毒）两种纳米材料相结合，成功地将一种普通的铁纳米材料变成了前所未有的癌症杀手。在线版本包含补充材料，可通过10.1186/s12951-022-01663-8获得。
In 2020, nearly 20 million peoples got cancer and nearly 10 million peoples died of cancer, indicating the cancer remains a great threat to human health and life. New therapies are still in urgent demand. We here develop a novel cancer therapy named Ferroptosis ASsassinates Tumor (FAST) by combining iron oxide nanoparticles with cancer-selective knockdown of seven key ferroptosis-resistant genes (FPN, LCN2, FTH1, FSP1, GPX4, SLC7A11, NRF2). We found that FAST had notable anti-tumor activity in a variety of cancer cells but little effect on normal cells. Especially, FAST eradicated three different types of tumors (leukemia, colon cancer, and lung metastatic melanoma) from over 50% of cancer mice, making the mice survive up to 250 days without tumor relapse. FAST also significantly inhibited and prevented the growth of spontaneous breast cancer and improved survival in mice. FAST showed high pan anti-tumor efficacy, high cancer specificity, and in vivo safety. FAST defines a new form of advanced nanomaterials, advanced combinatorial nanomaterials, by combining two kinds of nanomaterials, a chemical nanomaterial (iron oxide nanoparticles) and a biochemical nanomaterial (adeno-associated virus), which successfully turns a general iron nanomaterial into an unprecedented assassin to cancer. The online version contains supplementary material available at 10.1186/s12951-022-01663-8.
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影响因子：
64.5
作者：
Dixon SJ;Lemberg KM;Lamprecht MR;Skouta R;Zaitsev EM;Gleason CE;Patel DN;Bauer AJ;Cantley AM;Yang WS;Morrison B 3rd;Stockwell BR
通讯作者：
Stockwell BR
影响因子：
5.5
作者：
Chen X;Yu C;Kang R;Tang D
通讯作者：
Tang D
影响因子：
16.6
作者：
Gao J;Luo T;Wang J
通讯作者：
Wang J
DOI：
10.1126/science.aaw9872
发表时间：
2020-04-03
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Badgley MA;Kremer DM;Maurer HC;DelGiorno KE;Lee HJ;Purohit V;Sagalovskiy IR;Ma A;Kapilian J;Firl CEM;Decker AR;Sastra SA;Palermo CF;Andrade LR;Sajjakulnukit P;Zhang L;Tolstyka ZP;Hirschhorn T;Lamb C;Liu T;Gu W;Seeley ES;Stone E;Georgiou G;Manor U;Iuga A;Wahl GM;Stockwell BR;Lyssiotis CA;Olive KP
通讯作者：
Olive KP
影响因子：
64.8
作者：
Mao C;Liu X;Zhang Y;Lei G;Yan Y;Lee H;Koppula P;Wu S;Zhuang L;Fang B;Poyurovsky MV;Olszewski K;Gan B
通讯作者：
Gan B