RNA interference against viruses: strike and counterstrike.
RNA interference against viruses: strike and counterstrike.
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DOI：
10.1038/nbt1369
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发表时间：
2007-12
影响因子：
46.9
通讯作者：
Berkhout B
中科院分区：
文献类型：
--
作者：
Haasnoot J;Westerhout EM;Berkhout B
RNA干扰（RNAi）是由双链RNA诱导的一种保守的序列特异性基因沉默机制。RNAi作为一种新的基于核酸的治疗方法，对各种疾病，包括癌症，传染病和遗传性疾病具有很大的希望。抗病毒RNAi策略受到了广泛关注，目前正在临床试验中测试几种化合物。尽管诱导的RNAi能够引发对病毒复制的深刻和特异性抑制，但越来越清楚的是，RNAi疗法并不像我们最初希望的那样简单。关于毒性和传递到正确细胞的困难，早期阻碍了基于反义的治疗方法的发展，也可能适用于RNAi。此外，有迹象表明，病毒已经进化出逃避RNAi的方法。在设计基于RNAi的治疗剂以成功临床干预人类致病病毒时，适当考虑所有这些问题将是必要的。
RNA interference (RNAi) is a conserved sequence-specific, gene-silencing mechanism that is induced by double-stranded RNA. RNAi holds great promise as a novel nucleic acid–based therapeutic against a wide variety of diseases, including cancer, infectious diseases and genetic disorders. Antiviral RNAi strategies have received much attention and several compounds are currently being tested in clinical trials. Although induced RNAi is able to trigger profound and specific inhibition of virus replication, it is becoming clear that RNAi therapeutics are not as straightforward as we had initially hoped. Difficulties concerning toxicity and delivery to the right cells that earlier hampered the development of antisense-based therapeutics may also apply to RNAi. In addition, there are indications that viruses have evolved ways to escape from RNAi. Proper consideration of all of these issues will be necessary in the design of RNAi-based therapeutics for successful clinical intervention of human pathogenic viruses.
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