Intestinal Microbiota and Liver Diseases: Insights into Therapeutic Use of Traditional Chinese Medicine.
Intestinal Microbiota and Liver Diseases: Insights into Therapeutic Use of Traditional Chinese Medicine.
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DOI：
10.1155/2021/6682581
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Mao D
中科院分区：
文献类型：
--
作者：
Wang T;Huang S;Wu C;Wang N;Zhang R;Wang M;Mao D
肝病是全球发病率和死亡率的主要原因，炎症、饮酒、脂质代谢紊乱、胆汁酸代谢紊乱和内毒素是常见的危险因素。传统中医（TCM）以其“整体疗法”作为补充、替代疗法在世界范围内广泛使用，与传统药物相比，其临床疗效好，副作用少。然而，由于缺乏可靠的科学证据，中医药在肝病防治中的作用尚不清楚。近年来，随着高通量测序、16S rRNA检测和生物信息学方法的快速发展，人们逐渐认识到中医药调节肠道菌群在肝病治疗中可以发挥实质性作用。为了更好地了解中医药如何调节肠道菌群、抑制肝病，我们对现有研究结果进行回顾和分析，总结肠道菌群与肝病的关系及危险因素。本文综述了中医药影响肠道微生物组成和代谢物的相关机制。
Liver disease is a leading cause of global morbidity and mortality, for which inflammation, alcohol use, lipid metabolic disorders, disturbance to bile acid metabolism, and endotoxins are common risk factors. Traditional Chinese Medicine (TCM) with its “holistic approach” is widely used throughout the world as a complementary, alternative therapy, due to its clinical efficacy and reduced side effects compared with conventional medicines. However, due to a lack of reliable scientific evidence, the role of TCM in the prevention and treatment of liver disease remains unclear. Over recent years, with the rapid development of high-throughput sequencing, 16S rRNA detection, and bioinformatics methodology, it has been gradually recognized that the regulation of intestinal microbiota by TCM can play a substantial role in the treatment of liver disease. To better understand how TCM regulates the intestinal microbiota and suppresses liver disease, we have reviewed and analyzed the results of existing studies and summarized the relationship and risk factors between intestinal microbiota and liver disease. The present review summarizes the related mechanisms by which TCM affects the composition and metabolites of the intestinal microbiome.
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影响因子：
6.1
作者：
Guo, Wei-Ling;Pan, Yu-Yang;Lv, Xu-Cong
通讯作者：
Lv, Xu-Cong
影响因子：
13.5
作者：
Garcia-Rodriguez, Juan L.;Barbier-Torres, Lucia;Fernandez-Alvarez, Sara;Gutierrez-de Juan, Virginia;Monte, Maria J.;Halilbasic, Emina;Herranz, Daniel;Alvarez, Luis;Aspichueta, Patricia;Marin, Jose J. G.;Trauner, Michael;Mato, Jose M.;Serrano, Manuel;Beraza, Naiara;Luz Martinez-Chantar, Maria
通讯作者：
Luz Martinez-Chantar, Maria
影响因子：
17.1
作者：
Balmer, Maria L.;Slack, Emma;Macpherson, Andrew J.
通讯作者：
Macpherson, Andrew J.
影响因子：
15.5
作者：
Dubinkina VB;Tyakht AV;Odintsova VY;Yarygin KS;Kovarsky BA;Pavlenko AV;Ischenko DS;Popenko AS;Alexeev DG;Taraskina AY;Nasyrova RF;Krupitsky EM;Shalikiani NV;Bakulin IG;Shcherbakov PL;Skorodumova LO;Larin AK;Kostryukova ES;Abdulkhakov RA;Abdulkhakov SR;Malanin SY;Ismagilova RK;Grigoryeva TV;Ilina EN;Govorun VM
通讯作者：
Govorun VM
DOI：
10.1038/nrgastro.2017.32
发表时间：
2017-06
期刊：
Nature reviews. Gastroenterology & hepatology
影响因子：
--
作者：
Gluchowski NL;Becuwe M;Walther TC;Farese RV Jr
通讯作者：
Farese RV Jr