Serum inflammatory cytokine levels correlate with hand-foot-mouth disease severity: a nested serial case-control study.
Serum inflammatory cytokine levels correlate with hand-foot-mouth disease severity: a nested serial case-control study.
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DOI：
10.1371/journal.pone.0112676
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Fan Q
中科院分区：
文献类型：
--
作者：
Duan G;Yang H;Shi L;Sun W;Sui M;Zhang R;Wang X;Wang F;Zhang W;Xi Y;Fan Q
手足口病病例可能是致命的。这些病例发展迅速，预测手足口病从轻度到致命的严重程度和确定轻度手足口病的危险因素是很重要的。本研究的目的是将血清炎症细胞因子水平与手足口病严重程度联系起来。本研究设计为巢式系列病例对照研究。收集的数据包括一般信息、临床症状和体征、实验室结果和血清细胞因子水平。发病后第2 ~ 5天，重症手足口病患者血清IL-4、IL-6、IL-10、TNF-α、IFN-γ水平显著高于轻症患者。IL-4、IL-6、IL-10和IFN-γ水平在第2 ~ 4天呈上升趋势，随后呈下降趋势。TNF-α水平在前两天高，随后下降。对照组中IL-10、TNF-α、IFN-γ的变化相似。对照组中IL-4、IL-6、IL-17水平随手足口病进展无显著差异。我们的研究结果表明，IL-4、IL-6、IL-10、TNF-α和IFN-γ水平与手足口病的严重程度相关。
Hand-food-mouth disease (HFMD) cases can be fatal. These cases develop rapidly, and it is important to predict the severity of HFMD from mild to fatal and to identify risk factors for mild HFMD. The objective of this study was to correlate the levels of serum inflammatory cytokines with HFMD severity. This study was designed as a nested serial case-control study. The data collected included general information, clinical symptoms and signs, laboratory findings and serum cytokine levels. The levels of IL-4, IL-6, IL-10, TNF-α and IFN-γ in patients with severe HFMD were significantly higher than in mild patients during the 2nd to 5th day after disease onset. The levels of IL-4, IL-6, IL-10 and IFN-γ increased from the 2nd day to the 4th day and later decreased. The levels of TNF-α were high on the first two days and subsequently decreased. The changes of IL-10, TNF-α and IFN-γ in the controls were similar for all cases. The levels of IL-4, IL-6 and IL-17 in the controls were not significantly different with the progression of HFMD. Our findings indicate that the IL-4, IL-6, IL-10, TNF-α and IFN-γ levels correlate with HFMD severity.
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影响因子：
105.7
作者：
DUFF, MF
通讯作者：
DUFF, MF
影响因子：
5.5
作者：
Chung, Yao-Chi;Ho, Mei-Shang;Hu, Yu-Chen
通讯作者：
Hu, Yu-Chen
影响因子：
5.1
作者：
RICHARDSON, HB;LEIBOVITZ, A
通讯作者：
LEIBOVITZ, A
影响因子：
8.8
作者：
Liu, CC;Tseng, HW;Su, IJ
通讯作者：
Su, IJ
影响因子：
3.7
作者：
Lin, Ming-Tai;Wang, Jou-Kou;Wu, Mei-Hwan
通讯作者：
Wu, Mei-Hwan