Human herpesvirus-8/Kaposi's sarcoma-associated herpesvirus is a new transmissible virus that infects B cells.
Human herpesvirus-8/Kaposi's sarcoma-associated herpesvirus is a new transmissible virus that infects B cells.
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DOI：
10.1084/jem.183.5.2385
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发表时间：
1996-05-01
影响因子：
15.3
通讯作者：
Asch, AS
中科院分区：
文献类型：
--
作者：
Mesri, EA;Cesarman, E;Arvanitakis, L;Rafii, S;Moore, MAS;Posnett, DN;Knowles, DM;Asch, AS
Herpesviral DNA fragments isolated from AIDS-associated Kaposi's sarcoma (KS) tissue (KSHV-DNA) share homology with two lymphotropic oncogenic gamma-herpesviruses, Epstein-Barr virus and Herpesvirus saimiri, and are present in the lesions of more than 95% of HIV and non- HIV-associated forms of KS, AIDS-related body cavity-based lymphomas, and AIDS-related multicentric Castleman's disease. Here we show that BC- 1, a KSHV-DNA-positive, body cavity-based lymphoma cell line, produces infective herpesviral particles carrying a linear 270-kb genome that specifically transmits KSHV-DNA to CD19+ B cells. Transmission of KSHV- DNA is dependent upon a biologically active, replicating virus, since it is blocked by UV irradiation and foscarnet, an inhibitor of viral DNA-polymerase. This study represents the first isolation and transmission of the human herpesvirus-8/KS-associated herpesvirus.
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影响因子：
20.3
作者：
CESARMAN, E;MOORE, PS;CHANG, Y
通讯作者：
CHANG, Y
影响因子：
158.5
作者：
MOORE, PS;CHANG, Y
通讯作者：
CHANG, Y
影响因子：
56.9
作者：
AMBROZIAK, JA;BLACKBOURN, DJ;LEVY, JA
通讯作者：
LEVY, JA
影响因子：
56.9
作者：
FAUCI, AS
通讯作者：
FAUCI, AS
影响因子：
5.4
作者：
Moore, PS;Gao, SJ;Chang, Y
通讯作者：
Chang, Y