Matricellular protein thrombospondins: influence on ocular angiogenesis, wound healing and immuneregulation.
Matricellular protein thrombospondins: influence on ocular angiogenesis, wound healing and immuneregulation.
复制标题
DOI：
10.3109/02713683.2013.877936
复制
发表时间：
2014-08
影响因子：
2
通讯作者：
Zieske J
中科院分区：
文献类型：
--
作者：
Masli S;Sheibani N;Cursiefen C;Zieske J
血小板反应蛋白是一个大的多结构域糖蛋白家族，基于其与广泛的受体、基质分子、生长因子或蛋白酶相互作用以及调节一系列细胞功能（包括细胞内信号传导、增殖和迁移）的能力而被描述为基质细胞蛋白。血小板反应蛋白家族的两个成员，血小板反应蛋白1（TSP 1）和血小板反应蛋白2（TSP 2）被广泛研究，以确定其结构和功能。虽然在正常成人组织中以低水平表达，但其表达增加主要是响应于细胞扰动。尽管结构相似，但TSP 1和TSP 2之间显着的功能差异包括前者激活潜在TGF-β的能力以及后者对其竞争性抑制。据报道，这两种血小板反应蛋白在富含TGF-β的眼部环境中发挥重要作用，大多数报道与TSP 1有关。由许多眼部细胞类型表达并且在房水和玻璃体液中可检测到的TSP 1和TSP 2影响眼睛中的许多细胞相互作用，例如血管生成、细胞迁移、伤口愈合、TGF-β活化和炎症免疫应答的调节。已知这些过程共同促成眼睛的免疫特权状态。本文综述了TSP 1和TSP 2在眼功能和病理中的作用。
Thrombospondins are a family of large multi-domain glycoproteins described as matricelluar proteins based on their ability to interact with a broad range of receptors, matrix molecules, growth factors or proteases and to modulate array of cellular functions including intracellular signaling, proliferation and migration. Two members of the thrombospondin family, thrombospondin 1 (TSP1) and thrombospondin 2 (TSP2) are studied extensively to determine their structure and function. While expressed at low levels in normal adult tissues their increased expression is seen predominantly in response to cellular perturbations. Despite structural similarities a notable functional difference between TSP1 and TSP2 includes the ability of former to activate of latent TGF-β and its competitive inhibition by the latter. Both these thrombospondins are reported to play important roles in TGF-β rich ocular environment with most reports related to TSP1. Expressed by many ocular cell types and detectable in the aqueous and vitreous humor TSP1 and TSP2 influence many cellular interactions in the eye such as angiogenesis, cell migration, wound healing, TGF-β activation and regulation of inflammatory immune responses. Together these processes are known to contribute to the immune privilege status of the eye. Emerging roles of TSP1 and TSP2 in ocular functions and pathology are reviewed here.
登录
查看更多内容
DOI：
10.1083/jcb.138.3.707
发表时间：
1997-08-11
期刊：
The Journal of cell biology
影响因子：
--
作者：
Dawson DW;Pearce SF;Zhong R;Silverstein RL;Frazier WA;Bouck NP
通讯作者：
Bouck NP
DOI：
10.1073/pnas.0506112103
发表时间：
2006-07-25
影响因子：
11.1
作者：
Cursiefen, Claus;Chen, Lu;Dana, Reza
通讯作者：
Dana, Reza
影响因子：
2.1
作者：
Aiello, LP
通讯作者：
Aiello, LP
影响因子：
6.4
作者：
Cinatl, J;Bittoova, M;Doerr, HW
通讯作者：
Doerr, HW
影响因子：
4.4
作者：
Avice, MN;Rubio, M;Sarfati, M
通讯作者：
Sarfati, M