Associations between psychosocial factors and circulating cytokines in breast cancer survivors.
Associations between psychosocial factors and circulating cytokines in breast cancer survivors.
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DOI：
10.1080/08870446.2021.2003797
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发表时间：
2023-07
影响因子：
3.3
通讯作者：
Eisenberger, Naomi, I
中科院分区：
文献类型：
--
作者：
Leschak, Carrianne J.;Dutcher, Janine M.;Haltom, Kate E. Byrne;Breen, Elizabeth C.;Bower, Julienne E.;Eisenberger, Naomi, I
研究已经建立了社会隔离和促炎细胞因子水平升高之间的联系（例如，白细胞介素-6 [IL-6]，肿瘤坏死因子α [TNF-α]）。最新进展允许检查也可能在抗病毒免疫中发挥作用的细胞因子（干扰素-γ [IFN-γ]）。目前的工作探讨了社会经验的各种特征如何与乳腺癌幸存者的循环细胞因子相关，因为炎症与癌症复发和死亡率有关。女性乳腺癌幸存者（N = 43）完成了抽血，以评估促炎细胞因子（IL-6、TNF-α）的循环水平和与抗病毒免疫相关的细胞因子（IFN-γ）水平。我们研究了细胞因子和社会经验的不同方面之间的关联，包括家庭规模，心理健康和社会威胁焦虑。IFN-γ的循环水平与较大的家庭规模（r = 0.32，p = 0.04）和较高的社会心理健康水平（r = 0.33，p = 0.04）相关。此外，IL-6水平升高与社交威胁焦虑相关（r = 0.38，p = 0.01）。升高的IL-6也与家庭规模相关（r = 0.33，p = 0.03）。这些发现与工作一致，表明抗病毒免疫和炎症可能对社会经验与健康之间的联系有明显的贡献，特别是对于那些先前诊断患有乳腺癌的人。
Research has established links between social isolation and heightened levels of proinflammatory cytokines (e.g., interleukin-6 [IL-6], tumor necrosis factor alpha [TNF-α]). Recent advances allow for the examination of cytokines that may also play a role in antiviral immunity (interferon-gamma [IFN-γ]). The present work explored how various features of social experience relate to circulating cytokines in breast cancer survivors, as inflammation has been tied to cancer recurrence and mortality. Female breast cancer survivors (N=43) completed a blood draw to assess circulating levels of proinflammatory cytokines (IL-6, TNF-α) and levels of a cytokine that also relates to antiviral immunity (IFN-γ). We examined associations between cytokines and different aspects of social experience, including household size, psychosocial well-being, and social threat anxiety. Circulating levels of IFN-γ were associated with larger household size (r=0.32, p=0.04) and higher levels of psychosocial well-being (r=0.33, p=0.04). Additionally, heightened levels of IL-6 were associated with social threat anxiety (r=0.38, p=0.01). Heightened IL-6 was also associated with household size (r=0.33, p=0.03). These findings are consistent with work suggesting that antiviral immunity and inflammation may have distinct contributions to the links between social experience and health, particularly for those previously diagnosed with breast cancer.
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影响因子：
64.8
作者：
Filiano AJ;Xu Y;Tustison NJ;Marsh RL;Baker W;Smirnov I;Overall CC;Gadani SP;Turner SD;Weng Z;Peerzade SN;Chen H;Lee KS;Scott MM;Beenhakker MP;Litvak V;Kipnis J
通讯作者：
Kipnis J
影响因子：
8.2
作者：
Dickerson SS;Gable SL;Irwin MR;Aziz N;Kemeny ME
通讯作者：
Kemeny ME
影响因子：
10.6
作者：
Cole, SW;Kemeny, ME;Naliboff, BD
通讯作者：
Naliboff, BD
影响因子：
4.2
作者：
Almuneef, MA;Memish, ZA;Alsubaie, S
通讯作者：
Alsubaie, S
影响因子：
12.6
作者：
Holt-Lunstad, Julianne;Smith, Timothy B.;Stephenson, David
通讯作者：
Stephenson, David