The impacts of vaccination status and host factors during early infection on SARS-CoV-2 persistence:a retrospective single-center cohort study.
The impacts of vaccination status and host factors during early infection on SARS-CoV-2 persistence:a retrospective single-center cohort study.
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DOI：
10.1016/j.intimp.2022.109534
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发表时间：
2023-01
影响因子：
5.6
通讯作者：
Wan, Yanmin
中科院分区：
文献类型：
--
作者：
Tian, Xiangxiang;Zhang, Yifan;Wang, Wanhai;Fang, Fang;Zhang, Wenhong;Zhu, Zhaoqin;Wan, Yanmin
病毒的持久性是影响SARS-CoV-2传播力的关键因素。然而，疫苗接种和生理变量对病毒持久性的影响尚未得到充分澄清。我们收集了377例COVID-19患者的临床记录，其中包括未接种疫苗的患者和接受两剂灭活疫苗或mRNA疫苗的患者。分别分析疫苗接种对疾病严重程度和病毒持久性的影响，以及49个实验室变量与病毒持久性的相关性。最后，我们建立了一个多变量回归模型来预测病毒RNA的持久性。灭活疫苗和mRNA疫苗均可显著降低中度病例的发生率，而疫苗相关的病毒RNA持久性缩短仅在中度患者中观察到。相关性分析显示，未接种疫苗的轻度患者与接种灭活疫苗的轻度患者共有10个显著实验室变量，而接种mRNA疫苗的轻度患者无显著实验室变量。基于未接种疫苗的轻度患者中与病毒持久性相关的变量建立的多元回归模型可以预测除三名接种mRNA疫苗的中度患者外的所有患者的病毒RNA持久性。疫苗接种对COVID-19患者病毒RNA的清除作用有限。而早期感染的实验室变量可以预测病毒RNA的持久性。
Viral persistence is a crucial factor that influences the transmissibility of SARS-CoV-2. However, the impacts of vaccination and physiological variables on viral persistence have not been adequately clarified. We collected the clinical records of 377 COVID-19 patients, which contained unvaccinated patients and patients received two doses of an inactivated vaccine or an mRNA vaccine. The impacts of vaccination on disease severity and viral persistence and the correlations between 49 laboratory variables and viral persistence were analyzed separately. Finally, we established a multivariate regression model to predict the persistence of viral RNA. Both inactivated and mRNA vaccines significantly reduced the rate of moderate cases, while the vaccine related shortening of viral RNA persistence was only observed in moderate patients. Correlation analysis showed that 10 significant laboratory variables were shared by the unvaccinated mild patients and mild patients inoculated with an inactivated vaccine, but not by the mild patients inoculated with an mRNA vaccine. A multivariate regression model established based on the variables correlating with viral persistence in unvaccinated mild patients could predict the persistence of viral RNA for all patients except three moderate patients inoculated with an mRNA vaccine. Vaccination contributed limitedly to the clearance of viral RNA in COVID-19 patients. While, laboratory variables in early infection could predict the persistence of viral RNA.
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影响因子：
82.9
作者：
Levine-Tiefenbrun, Matan;Yelin, Idan;Kishony, Roy
通讯作者：
Kishony, Roy
影响因子：
8.1
作者：
Liu Q;Qin C;Liu M;Liu J
通讯作者：
Liu J
影响因子：
11.1
作者：
Liu, W.;Liu, Y.;Chen, Z.
通讯作者：
Chen, Z.
影响因子：
3.9
作者：
Manzulli V;Scioscia G;Giganti G;Capobianchi MR;Lacedonia D;Pace L;Cipolletta D;Tondo P;De Nittis R;Rondinone V;Serrecchia L;Parisi A;Galante D;Lo Caputo S;Santantonio TA;Moschetta D;Dattoli V;Fasanella A;Foschino Barbaro MP
通讯作者：
Foschino Barbaro MP
DOI：
10.1016/j.clim.2020.108611
发表时间：
2020-12
期刊：
Clinical immunology (Orlando, Fla.)
影响因子：
--
作者：
Gao C;Zhu L;Jin CC;Tong YX;Xiao AT;Zhang S
通讯作者：
Zhang S