Longevity is not influenced by prenatal programming of body size.
Longevity is not influenced by prenatal programming of body size.
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DOI：
10.1111/j.1474-9726.2010.00589.x
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发表时间：
2010-08
期刊：
影响因子：
7.8
通讯作者：
Mason MA
中科院分区：
文献类型：
--
作者：
Conover CA;Bale LK;Grell JA;Mader JR;Mason MA
胰岛素样生长因子（IGF）信号传导对于在胎儿发育期间实现最佳体型是必不可少的，而在成人中，IGF与衰老和年龄相关疾病相关。然而，目前还不清楚发育过程中发生的事件在多大程度上影响寿命。在这里，我们提供了直接的证据表明，具有改变的IGF信号的小鼠的异常长寿与产前体型规划无关。妊娠相关血浆蛋白-A（PAPP-A）（一种IGF结合蛋白蛋白酶，可增加局部IGF生物利用度）无效的小鼠在出生时是其野生型同窝仔大小的60-70%，并延长了30- 40%的中位和最大寿命。在这项研究中，PAPP-A−/−小鼠的身体大小在胎儿发育期间通过破坏IgfII印记而正常化，并没有失去它们的长寿优势。通过PAPP-A抑制IGF信号的成人特异性调节可能提供了一个独特的机会来改善寿命，而不影响早期生命生理学的重要方面。
Insulin-like growth factor (IGF) signaling is essential for achieving optimal body size during fetal development, whereas, in the adult, IGFs are associated with aging and age-related diseases. However, it is unclear as to what extent lifespan is influenced by events that occur during development. Here we provide direct evidence that the exceptional longevity of mice with altered IGF signaling is not linked to prenatal programming of body size. Mice null for pregnancy-associated plasma protein-A (PAPP-A), an IGF binding protein proteinase that increases local IGF bioavailability, are 60–70% the size of their wild-type littermates at birth and have extended median and maximum lifespan of 30–40%. In this study, PAPP-A−/− mice whose body size was normalized during fetal development through disruption of IgfII imprinting, did not lose their longevity advantage. Adult-specific moderation of IGF signaling through PAPP-A inhibition may present a unique opportunity to improve lifespan without affecting important aspects of early life physiology.
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影响因子：
4
作者：
Bale, LK;Conover, CA
通讯作者：
Conover, CA
DOI：
10.1093/gerona/63.9.895
发表时间：
2008-09
期刊：
The journals of gerontology. Series A, Biological sciences and medical sciences
影响因子：
--
作者：
Swindell WR;Harper JM;Miller RA
通讯作者：
Miller RA
DOI：
10.1073/pnas.0705467105
发表时间：
2008-03-04
影响因子：
11.1
作者：
Suh, Yousin;Atzmon, Gil;Cohen, Pinchas
通讯作者：
Cohen, Pinchas
影响因子：
2.9
作者：
Rollo, CD
通讯作者：
Rollo, CD
影响因子：
56.9
作者：
Sutter, Nathan B.;Bustamante, Carlos D.;Ostrander, Elaine A.
通讯作者：
Ostrander, Elaine A.