Levels of Inflammatory Cytokines IL-1β, IL-6, IL-8, IL-17A, and TNF-α in Aqueous Humour of Patients with Diabetic Retinopathy.
Levels of Inflammatory Cytokines IL-1β, IL-6, IL-8, IL-17A, and TNF-α in Aqueous Humour of Patients with Diabetic Retinopathy.
复制标题
糖尿病视网膜病变患者房水中炎症细胞因子IL-1β、IL-6、IL-8、IL-17A和TNF-α水平
DOI：
10.1155/2018/8546423
复制
发表时间：
2018
影响因子：
4.3
通讯作者：
Yuan L
中科院分区：
文献类型：
--
作者：
Feng S;Yu H;Yu Y;Geng Y;Li D;Yang C;Lv Q;Lu L;Liu T;Li G;Yuan L
糖尿病视网膜病变是发达国家工作年龄人群失明的主要原因。然而，炎症在DR发病机制中的作用尚不完全清楚。这是一项观察性临床研究，纳入了80例II型糖尿病患者，他们接受了白内障手术，无论是DR或没有DR。所有病例均进一步分类的视网膜新生血管的增殖阶段和糖尿病史的长度。检测房水中炎性细胞因子IL-1β、IL-6、IL-8、IL-17和TNF-α的水平。本研究的结果表明，这些细胞因子水平在DR患者中升高，并可能对这种疾病的发病机制具有协同作用。随着新生血管的发展，它们也沿着升高，反映了DR的严重程度。结果还表明，对于糖尿病患者，这些水平越高，视网膜并发症可能出现得越早。结论：房水中炎性细胞因子IL-1β、IL-6、IL-8、IL-17 A和TNF-α的水平可能与DR的发病机制、严重程度和预后有关。
Diabetic retinopathy is the leading cause of blindness in working age individuals in developed countries. However, the role of inflammation in the pathogenesis of DR is not completely understood. This is an observational clinical research enrolling 80 type II diabetic patients who had undergone cataract surgeries either with DR or without DR. All cases were further categorized by the proliferative stages of retinal neovascularization and by the lengths of diabetic history. The levels of inflammatory cytokines including IL-1β, IL-6, IL-8, IL-17, and TNF-α in aqueous humour were tested. Results in this study indicated that these cytokine levels were increased in DR patients and might have a synergistic effect on the pathogenesis of this disease. They were also elevated along with the progression of neovascularization, reflecting the severity of DR. The results also suggested that for diabetic patients, the higher these levels are, the sooner retinal complications might appear. In conclusion, the levels of inflammatory cytokines IL-1β, IL-6, IL-8, IL-17A, and TNF-α in aqueous humour may be associated with the pathogenesis, severity, and prognosis of DR.
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影响因子：
5.1
作者：
Guariguata, L.;Whiting, D. R.;Shaw, J. E.
通讯作者：
Shaw, J. E.
影响因子：
--
作者：
Kern, Timothy S.
通讯作者：
Kern, Timothy S.
影响因子：
2.7
作者：
Brucklacher, Robert M.;Patel, Kruti M.;Freeman, Willard M.
通讯作者：
Freeman, Willard M.
DOI：
10.1111/j.1440-1681.1997.tb02133.x
发表时间：
1997-09-01
影响因子：
2.9
作者：
Alder, VA;Su, EN;Yu, PK
通讯作者：
Yu, PK
影响因子：
158.5
作者：
Holman, Rury R.;Paul, Sanjoy K.;Neil, H. Andrew W.
通讯作者：
Neil, H. Andrew W.