Robust dual-module velocity-selective arterial spin labeling (dm-VSASL) with velocity-selective saturation and inversion.
Robust dual-module velocity-selective arterial spin labeling (dm-VSASL) with velocity-selective saturation and inversion.
复制标题
具有速度选择性饱和度和反转的稳健双模型速度选择性动脉自旋标记(DM-VSASL)。
DOI:
10.1002/mrm.29513
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发表时间:
2023-03
影响因子:
3.3
通讯作者:
Guo, Jia
中科院分区:
文献类型:
--
作者:
Guo, Jia
关键词:
Compared to conventional arterial spin labeling (ASL) methods, velocity-selective ASL (VSASL) is more sensitive to artefacts from eddy currents, diffusion attenuation and motion. Background suppression (BS) is typically suboptimal in VSASL, especially of CSF. As a result, the temporal SNR (tSNR) and quantification accuracy of VSASL are compromised, hindering its application despite its advantage of being delay-insensitive. A novel dual-module VSASL (dm-VSASL) strategy is developed to improve the SNR efficiency and the tSNR with a more balanced gradient configuration in the label/control image acquisition. This strategy applies for both VS saturation (VSS) and VS inversion (VSI) labeling. The dm-VSASL schemes were compared with single-module labeling and a previously developed multi-module schemes for the SNR performance, BS efficacy and sensitivity to artefacts in simulation and in vivo experiments, using pulsed ASL as the reference. Dm-VSASL enabled more robust labeling and efficient BS across brain tissues, especially of CSF, resulting in significantly reduced artefacts and improved tSNR. Compared to single-module labeling, dm-VSASL significantly improved the tSNR in gray (by 90.8% and 94.9% for dm-VSS and dm-VSI, respectively, P < 0.001) and white (by 41.5% and 55.1% for dm-VSS and dm-VSI, respectively, P < 0.002) matter. Dm-VSI also improved the SNR of VSI by 5.4% (P = 0.018). Dm-VSASL can significantly improve the robustness of VS labeling, reduce artefacts, and allow efficient BS. When implemented with VSI, it provides the highest SNR efficiency among VSASL methods. Dm-VSASL is a powerful ASL method for robust, accurate and delay-insensitive perfusion mapping.
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影响因子:
3.3
作者:
Guo, Jia;Wong, Eric C.
通讯作者:
Wong, Eric C.
影响因子:
3.3
作者:
Meakin, James A.;Jezzard, Peter
通讯作者:
Jezzard, Peter
影响因子:
3.3
作者:
de Rochefort, L;Maître, X;Durand, E
通讯作者:
Durand, E
影响因子:
3.3
作者:
Guo, Jia;Das, Shaurov;Hernandez-Garcia, Luis
通讯作者:
Hernandez-Garcia, Luis
影响因子:
3.3
作者:
DETRE, JA;LEIGH, JS;KORETSKY, AP
通讯作者:
KORETSKY, AP