Free Testosterone Reflects Metabolic as well as Ovarian Disturbances in Subfertile Oligomenorrheic Women.
Free Testosterone Reflects Metabolic as well as Ovarian Disturbances in Subfertile Oligomenorrheic Women.
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DOI：
10.1155/2018/7956951
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发表时间：
2018
影响因子：
2.8
通讯作者：
Vanderschueren D
中科院分区：
文献类型：
--
作者：
Antonio L;Pauwels S;Laurent MR;Vanschoubroeck D;Jans I;Billen J;Claessens F;Decallonne B;De Neubourg D;Vermeersch P;Vanderschueren D
诊断多囊卵巢综合征（PCOS）是基于排卵功能障碍，卵巢超声数据，雄激素过多。总睾酮常用于识别雄激素过多，但睾酮主要与性激素结合球蛋白（SHBG）和白蛋白结合。只有1 - 2%的非蛋白结合睾酮（所谓的游离睾酮）具有生物活性，并负责雄激素的作用。此外，经常用于女性睾酮测量的自动免疫测定是不准确的。 评估液相色谱-串联质谱法测量的睾酮和计算的游离睾酮在月经过少和疑似PCOS的生育诊所就诊的低生育力妇女中的临床用途。 评估激素和代谢参数，并进行卵巢超声检查。采用液相色谱-串联质谱法测定总睾酮。从总睾酮和SHBG计算游离睾酮。 66名女性被纳入研究。总睾酮与卵巢体积和窦卵泡计数相关，但与代谢参数无关。然而，SHBG和计算的游离睾酮与卵巢超声和代谢参数（如BMI和胰岛素抵抗）相关。 评估SHBG和游离睾酮对于评估排卵功能障碍和疑似PCOS的低生育力女性的雄激素过多非常重要，因为它反映了卵巢和代谢紊乱。
Diagnosing polycystic ovary syndrome (PCOS) is based on ovulatory dysfunction, ovarian ultrasound data, and androgen excess. Total testosterone is frequently used to identify androgen excess, but testosterone is mainly bound to sex hormone-binding globulin (SHBG) and albumin. Only 1-2% of nonprotein-bound testosterone (so-called free testosterone) is biologically active and responsible for androgen action. Moreover, automated immunoassays which are frequently used for female testosterone measurements are inaccurate. To assess the clinical usefulness of liquid chromatography-tandem mass spectrometry measured testosterone and calculated free testosterone in subfertile women attending a fertility clinic with oligomenorrhea and suspected PCOS. Hormonal and metabolic parameters were evaluated, and ovarian ultrasound was performed. Total testosterone was measured by liquid chromatography-tandem mass spectrometry. Free testosterone was calculated from total testosterone and SHBG. Sixty-six women were included in the study. Total testosterone was associated with ovarian volume and antral follicle count but not with metabolic parameters. However, SHBG and calculated free testosterone were associated with both ovarian ultrasound and metabolic parameters, such as BMI and insulin resistance. Assessing SHBG and free testosterone is important in evaluating androgen excess in subfertile women with ovulatory dysfunction and suspected PCOS, as it reflects both ovarian and metabolic disturbances.
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DOI：
10.1111/j.1471-0528.2006.01008.x
发表时间：
2006-10-01
影响因子：
5.8
作者：
Broekmans, F. J.;Knauff, E. A. H.;Fauser, B. C. J. M.
通讯作者：
Fauser, B. C. J. M.
影响因子：
5.2
作者：
Alviggi C;Conforti A;De Rosa P;Strina I;Palomba S;Vallone R;Gizzo S;Borrelli R;Andersen CY;De Placido G;Guerriero S
通讯作者：
Guerriero S
影响因子：
3.7
作者：
Lerchbaum E;Schwetz V;Rabe T;Giuliani A;Obermayer-Pietsch B
通讯作者：
Obermayer-Pietsch B
DOI：
10.1016/s0889-8545(02)00008-6
发表时间：
2002-09-01
影响因子：
3.2
作者：
Hammond, GL
通讯作者：
Hammond, GL
影响因子：
5.8
作者：
Tosi, Flavia;Fiers, Tom;Moghetti, Paolo
通讯作者：
Moghetti, Paolo