Hyperandrogenemia in polycystic ovary syndrome: exploration of the role of free testosterone and androstenedione in metabolic phenotype.
Hyperandrogenemia in polycystic ovary syndrome: exploration of the role of free testosterone and androstenedione in metabolic phenotype.
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DOI：
10.1371/journal.pone.0108263
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Obermayer-Pietsch B
中科院分区：
文献类型：
--
作者：
Lerchbaum E;Schwetz V;Rabe T;Giuliani A;Obermayer-Pietsch B
评价雄烯二酮、睾酮和游离睾酮与多囊卵巢综合征代谢紊乱之间的关系。我们在一项横断面研究中分析了雄烯二酮、睾酮和游离睾酮与代谢参数之间的关系，该研究包括706名多囊卵巢综合征患者和140名BMI匹配的健康女性。将多囊卵巢综合征患者分为4组：雄烯二酮正常、游离睾酮正常（NA/NFT）、雄烯二酮升高、游离睾酮正常（HA/NFT）、雄烯二酮正常、游离睾酮升高（NA/HFT）、雄烯二酮升高、游离睾酮升高（HA/HFT）。与NA/NFT相比，游离睾酮水平升高的多囊卵巢综合征女性（HA/HFT和NA/HFT）具有不良代谢特征，包括2小时葡萄糖、HbA 1c、空腹和2小时胰岛素、胰岛素反应曲线下面积、胰岛素抵抗、胰岛素敏感性指数（Matsuda）、甘油三酯、总胆固醇和高密度脂蛋白胆固醇水平（所有年龄和BMI校正分析的p<0.05）。在调整年龄和BMI的二元logistic回归分析中，HA/HFT与NA/NFT的多囊卵巢综合征女性胰岛素抵抗的比值比为2.78（1.34-5.75，p=0.006）。 我们发现HA/NFT的多囊卵巢综合征妇女代谢紊乱的风险没有显著增加。在多元线性回归分析（年龄和BMI校正）中，我们发现雄烯二酮/游离睾酮比值与胰岛素反应曲线下面积、胰岛素抵抗和总胆固醇/高密度脂蛋白胆固醇比值呈显著负相关，与Matsuda指数和高密度脂蛋白胆固醇呈正相关（所有p<0.05）。多囊卵巢综合征妇女游离睾酮水平升高，但不是孤立的雄烯二酮升高有不利的代谢表型。此外，较高的雄烯二酮/游离睾酮比率与有益的代谢特征独立相关。
To evaluate the association between androstenedione, testosterone, and free testosterone and metabolic disturbances in polycystic ovary syndrome. We analyzed the association between androstenedione, testosterone, and free testosterone and metabolic parameters in a cross-sectional study including 706 polycystic ovary syndrome and 140 BMI-matched healthy women. Polycystic ovary syndrome women were categorized into 4 groups: normal androstenedione and normal free testosterone (NA/NFT), elevated androstenedione and normal free testosterone (HA/NFT), normal androstenedione and elevated free testosterone (NA/HFT), elevated androstenedione and free testosterone (HA/HFT). Polycystic ovary syndrome women with elevated free testosterone levels (HA/HFT and NA/HFT) have an adverse metabolic profile including 2 h glucose, HbA1c, fasting and 2 h insulin, area under the insulin response curve, insulin resistance, insulin sensitivity index (Matsuda), triglycerides, total and high density lipoprotein cholesterol levels compared to NA/NFT (p<0.05 for all age- and BMI-adjusted analyses). In binary logistic regression analysis adjusted for age and BMI, odds ratio for insulin resistance was 2.78 (1.34–5.75, p = 0.006) for polycystic ovary syndrome women with HA/HFT compared to NA/NFT. We found no significantly increased risk of metabolic disorders in polycystic ovary syndrome women with HA/NFT. In multiple linear regression analyses (age- and BMI-adjusted), we found a significant negative association between androstenedione/free testosterone-ratio and area under the insulin response curve, insulin resistance, and total cholesterol/high density lipoprotein cholesterol-ratio and a positive association with Matsuda-index, and high density lipoprotein cholesterol (p<0.05 for all). Polycystic ovary syndrome women with elevated free testosterone levels but not with isolated androstenedione elevation have an adverse metabolic phenotype. Further, a higher androstenedione/free testosterone-ratio was independently associated with a beneficial metabolic profile.
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影响因子：
9.8
作者：
Bernasconi, D;DelMonte, P;Marugo, M
通讯作者：
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Lerchbaum, Elisabeth;Giuliani, Albrecht;Obermayer-Pietsch, Barbara
通讯作者：
Obermayer-Pietsch, Barbara